Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Hypocholesterolemia in clinically serious conditions - review

Pavel Vyroubal, Carlo Chiarla, Ivo Giovannini, Radek Hyspler, Alena Ticha, Dana Hrnciarikova, Zdenek Zadak

Jazyk angličtina Země Česko

Typ dokumentu přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc10009387

Grantová podpora
NR8921 MZ0 CEP - Centrální evidence projektů

Background: Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids andother components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demandingprocess. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown.During stressful situations a signifi cant hypocholesterolaemia may be found. Hypocholesterolemia has been knownfor a number of years to be a signifi cant prognostic indicator of increased morbidity and mortality connected with awhole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemiaduring the intensive care. .Methods and Results: We examined studies that are engaged in problems of hypocholesterolemia in critically ill.Very low levels of total as well as LDL cholesterol are most frequently found in serious polytrauma, after extensivesurgery, in serious infections, in protracted hypovolemic shock. It is still not clear whether hypocholesterolemia refl ectsonly a serious metabolic disorder, which results from a life-threatening condition, or whether it has an active role inevolution and outcome.Conclusions: Hypocholesterolemia is commonly observed in critically ill patients. Nevertheless, it is not knownwhether it is a secondary manifestation of disease, or whether it actively contributes to deterioration of the disease.Although the contribution of hypocholesterolemia to mortality is modest compared with known risk factors such asincreased severity of illness and the development of nosocomial infection, low serum lipid concentrations representa potential therapeutic target in sepsis.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 99

000      
00000naa 2200000 a 4500
001      
bmc10009387
003      
CZ-PrNML
005      
20140312123742.0
008      
100420s2008 xr e eng||
009      
AR
024    7_
$a 10.5507/bp.2008.029 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Vyroubal, Pavel, $7 xx0080779 $d 1967-
245    10
$a Hypocholesterolemia in clinically serious conditions - review / $c Pavel Vyroubal, Carlo Chiarla, Ivo Giovannini, Radek Hyspler, Alena Ticha, Dana Hrnciarikova, Zdenek Zadak
314    __
$a Department of Gerontology and Metabolism, Faculty Hospital and Faculty of Medicine, Hradec Kralove
504    __
$a Lit.: 99
520    9_
$a Background: Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids andother components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demandingprocess. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown.During stressful situations a signifi cant hypocholesterolaemia may be found. Hypocholesterolemia has been knownfor a number of years to be a signifi cant prognostic indicator of increased morbidity and mortality connected with awhole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemiaduring the intensive care. .Methods and Results: We examined studies that are engaged in problems of hypocholesterolemia in critically ill.Very low levels of total as well as LDL cholesterol are most frequently found in serious polytrauma, after extensivesurgery, in serious infections, in protracted hypovolemic shock. It is still not clear whether hypocholesterolemia refl ectsonly a serious metabolic disorder, which results from a life-threatening condition, or whether it has an active role inevolution and outcome.Conclusions: Hypocholesterolemia is commonly observed in critically ill patients. Nevertheless, it is not knownwhether it is a secondary manifestation of disease, or whether it actively contributes to deterioration of the disease.Although the contribution of hypocholesterolemia to mortality is modest compared with known risk factors such asincreased severity of illness and the development of nosocomial infection, low serum lipid concentrations representa potential therapeutic target in sepsis.
650    _2
$a cholesterol $x nedostatek $7 D002784
650    _2
$a kritický stav $7 D016638
650    _2
$a chronická nemoc $7 D002908
650    _2
$a akutní nemoc $7 D000208
650    _2
$a jednotky intenzivní péče $7 D007362
650    _2
$a psychický stres $x komplikace $x metabolismus $7 D013315
650    _2
$a hypolipoproteinemie $x mortalita $x patologie $7 D007009
650    _2
$a LDL-cholesterol $x izolace a purifikace $x metabolismus $7 D008078
650    _2
$a polytrauma $x metabolismus $7 D009104
650    _2
$a chirurgie operační $x škodlivé účinky $7 D013514
650    _2
$a hemoragický šok $x metabolismus $7 D012771
650    _2
$a cytokiny $x izolace a purifikace $x metabolismus $7 D016207
650    _2
$a sepse $x etiologie $x metabolismus $x terapie $7 D018805
650    _2
$a syndrom systémové zánětlivé reakce $x etiologie $x komplikace $x terapie $7 D018746
650    _2
$a medicína založená na důkazech $x trendy $7 D019317
650    _2
$a lidé $7 D006801
650    _2
$a financování organizované $7 D005381
655    _2
$a přehledy $7 D016454
700    1_
$a Chiarla, Carlo
700    1_
$a Giovannini, Ivo
700    1_
$a Hyšpler, Radomír, $d 1972- $7 nlk20040155091
700    1_
$a Tichá, Alena, $d 1976- $7 xx0076494
700    1_
$a Hrnčiariková, Dana, $d 1977- $7 xx0081898
700    1_
$a Zadák, Zdeněk, $d 1937- $7 nlk19990074064
773    0_
$w MED00012606 $t Biomedical papers $g Roč. 152, č. 2 (2008), s. 181-189 $x 1213-8118
856    41
$u http://biomed.papers.upol.cz/pdfs/bio/2008/02/01.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 1502 $c 958 $y 8 $z 0
990    __
$a 20100419115931 $b ABA008
991    __
$a 20140312123751 $b ABA008
999    __
$a ok $b bmc $g 723262 $s 586377
BAS    __
$a 3
BMC    __
$a 2008 $b 152 $c 2 $d 181-189 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $x MED00012606
GRA    __
$a NR8921 $p MZ0
LZP    __
$a 2010-22/dkal

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...