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Hypocholesterolemia in clinically serious conditions - review
Pavel Vyroubal, Carlo Chiarla, Ivo Giovannini, Radek Hyspler, Alena Ticha, Dana Hrnciarikova, Zdenek Zadak
Jazyk angličtina Země Česko
Typ dokumentu přehledy
Grantová podpora
NR8921
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
Directory of Open Access Journals
od 2001
Free Medical Journals
od 1998
Medline Complete (EBSCOhost)
od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
- MeSH
- akutní nemoc MeSH
- chirurgie operační škodlivé účinky MeSH
- cholesterol nedostatek MeSH
- chronická nemoc MeSH
- cytokiny izolace a purifikace metabolismus MeSH
- financování organizované MeSH
- hemoragický šok metabolismus MeSH
- hypolipoproteinemie mortalita patologie MeSH
- jednotky intenzivní péče MeSH
- kritický stav MeSH
- LDL-cholesterol izolace a purifikace metabolismus MeSH
- lidé MeSH
- medicína založená na důkazech trendy MeSH
- polytrauma metabolismus MeSH
- psychický stres komplikace metabolismus MeSH
- sepse etiologie metabolismus terapie MeSH
- syndrom systémové zánětlivé reakce etiologie komplikace terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Background: Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids andother components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demandingprocess. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown.During stressful situations a signifi cant hypocholesterolaemia may be found. Hypocholesterolemia has been knownfor a number of years to be a signifi cant prognostic indicator of increased morbidity and mortality connected with awhole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemiaduring the intensive care. .Methods and Results: We examined studies that are engaged in problems of hypocholesterolemia in critically ill.Very low levels of total as well as LDL cholesterol are most frequently found in serious polytrauma, after extensivesurgery, in serious infections, in protracted hypovolemic shock. It is still not clear whether hypocholesterolemia refl ectsonly a serious metabolic disorder, which results from a life-threatening condition, or whether it has an active role inevolution and outcome.Conclusions: Hypocholesterolemia is commonly observed in critically ill patients. Nevertheless, it is not knownwhether it is a secondary manifestation of disease, or whether it actively contributes to deterioration of the disease.Although the contribution of hypocholesterolemia to mortality is modest compared with known risk factors such asincreased severity of illness and the development of nosocomial infection, low serum lipid concentrations representa potential therapeutic target in sepsis.
Citace poskytuje Crossref.org
Lit.: 99
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- $a Department of Gerontology and Metabolism, Faculty Hospital and Faculty of Medicine, Hradec Kralove
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- $a Background: Cholesterol is an essential component of cell membranes, precursor of steroids, biliary acids andother components of serious importance in live organism. Cholesterol synthesis is a complicated and energy-demandingprocess. Real daily need of cholesterol and mechanisms of decline cholesterol levels in critical ill are unknown.During stressful situations a signifi cant hypocholesterolaemia may be found. Hypocholesterolemia has been knownfor a number of years to be a signifi cant prognostic indicator of increased morbidity and mortality connected with awhole spectrum of pathological conditions. The aim of article is the elucidation of the role and importance of hypocholesterolaemiaduring the intensive care. .Methods and Results: We examined studies that are engaged in problems of hypocholesterolemia in critically ill.Very low levels of total as well as LDL cholesterol are most frequently found in serious polytrauma, after extensivesurgery, in serious infections, in protracted hypovolemic shock. It is still not clear whether hypocholesterolemia refl ectsonly a serious metabolic disorder, which results from a life-threatening condition, or whether it has an active role inevolution and outcome.Conclusions: Hypocholesterolemia is commonly observed in critically ill patients. Nevertheless, it is not knownwhether it is a secondary manifestation of disease, or whether it actively contributes to deterioration of the disease.Although the contribution of hypocholesterolemia to mortality is modest compared with known risk factors such asincreased severity of illness and the development of nosocomial infection, low serum lipid concentrations representa potential therapeutic target in sepsis.
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