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Muscle lymphocytic infiltrates in thymoma-associated myasthenia gravis are phenotypically different from those in polymyositis
J. Zamecnik, D. Vesely, B. Jakubicka, L. Simkova, J. Pitha, J. Schutzner, R. Mazanec, H. Vogel
Language English Country Great Britain
Grant support
NR8924
MZ0
CEP Register
- MeSH
- Lymphocyte Activation MeSH
- Leukocyte Common Antigens immunology MeSH
- CD8 Antigens immunology MeSH
- Biomarkers analysis metabolism MeSH
- Biopsy MeSH
- Cell Differentiation MeSH
- Diagnosis, Differential MeSH
- Adult MeSH
- Phenotype MeSH
- Financing, Organized MeSH
- Muscle, Skeletal immunology pathology physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphocytes immunology pathology MeSH
- Myasthenia Gravis immunology physiopathology pathology MeSH
- Polymyositis immunology physiopathology pathology MeSH
- Cell Proliferation MeSH
- Aged MeSH
- Thymoma immunology complications physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
The aim of the study is to provide evidence that the lymphocytic infiltration of myasthenia gravis (MG) muscle do not represent a true autoimmune myositis, rather an infiltration by naive lymphocytes derived from lymphocyte-rich thymomas. Muscle biopsies from 179 patients with pure MG, 6 thymoma patients without MG and 15 patients with definite polymyositis were analyzed. In 18 patients with MG (all associated with lymphocyte-rich thymomas) and in two thymoma patients without MG, lymphocytic infiltrates were identified in muscles. By use of immunohistochemistry, we demonstrated that the lymphocytes in MG differ from those in polymyositis, being mature but in contrast to polymyositis naive CD45RA+ T lymphocytes. We suggest that the lymphocytic infiltrates in patients with MG and thymoma represent an infiltration of muscle by thymoma-derived mature but naive T cells. The finding of CD8+CD45RA+ lymphocytes in muscle may signify an underlying thymoma and should not be misdiagnosed as polymyositis.
References provided by Crossref.org
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- $a The aim of the study is to provide evidence that the lymphocytic infiltration of myasthenia gravis (MG) muscle do not represent a true autoimmune myositis, rather an infiltration by naive lymphocytes derived from lymphocyte-rich thymomas. Muscle biopsies from 179 patients with pure MG, 6 thymoma patients without MG and 15 patients with definite polymyositis were analyzed. In 18 patients with MG (all associated with lymphocyte-rich thymomas) and in two thymoma patients without MG, lymphocytic infiltrates were identified in muscles. By use of immunohistochemistry, we demonstrated that the lymphocytes in MG differ from those in polymyositis, being mature but in contrast to polymyositis naive CD45RA+ T lymphocytes. We suggest that the lymphocytic infiltrates in patients with MG and thymoma represent an infiltration of muscle by thymoma-derived mature but naive T cells. The finding of CD8+CD45RA+ lymphocytes in muscle may signify an underlying thymoma and should not be misdiagnosed as polymyositis.
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