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Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment
A. Zdarilova, E. Vrublova, J. Vostalova, B. Klejdus, D. Stejskal, J. Proskova, P. Kosina, A. Svobodova, R. Vecera, J. Hrbac, D. Cernochova, J. Vicar, J. Ulrichova, V. Simanek
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Benzophenanthridines analysis MeSH
- Diet MeSH
- Feces chemistry MeSH
- Isoquinolines analysis MeSH
- Liver enzymology drug effects MeSH
- Blood Cell Count MeSH
- Animal Feed analysis toxicity MeSH
- Rats MeSH
- Drugs, Chinese Herbal analysis toxicity MeSH
- Oxidative Stress drug effects MeSH
- Papaveraceae chemistry MeSH
- Pilot Projects MeSH
- Rats, Wistar MeSH
- Food Additives analysis toxicity MeSH
- Eating MeSH
- Cytochrome P-450 Enzyme System analysis metabolism MeSH
- Body Weight drug effects MeSH
- Tissue Distribution MeSH
- Organ Size drug effects MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Macleaya cordata (Willd.) (Papaveraceae) is used as an active component in the natural feed additive Sangrovit. Sangrovit contains mixture of the intact aerial parts and the fraction of quaternary benzo[c]phenanthridine alkaloids from M. cordata (FQBA). In a 90-day pilot toxicity trial, Sangrovit and the FQBA were tested for safety. Male Wistar rats were fed for 90 days with 100, 7000 or 14000mg of Sangrovit or 600mg of FQBA in 1kg of feed. Body and organ weights, clinical chemistry and hematology markers, oxidative stress parameters, morphological structure of tongue, liver, ileum, kidney and heart samples, and total cytochrome P450 in liver were monitored. The results showed no statistically significant alterations in any parameter between control and treated animals, except for the group treated with 14000ppm Sangrovit that resulted in elevation of reduced glutathione level and superoxide dismutase activity in liver.
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- $a Macleaya cordata (Willd.) (Papaveraceae) is used as an active component in the natural feed additive Sangrovit. Sangrovit contains mixture of the intact aerial parts and the fraction of quaternary benzo[c]phenanthridine alkaloids from M. cordata (FQBA). In a 90-day pilot toxicity trial, Sangrovit and the FQBA were tested for safety. Male Wistar rats were fed for 90 days with 100, 7000 or 14000mg of Sangrovit or 600mg of FQBA in 1kg of feed. Body and organ weights, clinical chemistry and hematology markers, oxidative stress parameters, morphological structure of tongue, liver, ileum, kidney and heart samples, and total cytochrome P450 in liver were monitored. The results showed no statistically significant alterations in any parameter between control and treated animals, except for the group treated with 14000ppm Sangrovit that resulted in elevation of reduced glutathione level and superoxide dismutase activity in liver.
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