Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy

J. Harper, J. Geraedts, P. Borry, MC. Cornel, WJ. Dondorp, L. Gianaroli, G. Harton, T. Milachich, H. Kääriäinen, I. Liebaers, M. Morris, J. Sequeiros, K. Sermon, F. Shenfield, H. Skirton, S. Soini, C. Spits, A. Veiga, JR. Vermeesch, S. Viville,...

. 2014 ; 29 (8) : 1603-9.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15023269

STUDY QUESTION: How has the interface between genetics and assisted reproduction technology (ART) evolved since 2005? SUMMARY ANSWER: The interface between ART and genetics has become more entwined as we increase our understanding about the genetics of infertility and we are able to perform more comprehensive genetic testing. WHAT IS KNOWN ALREADY: In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and ART and published an extended background paper, recommendations and two Editorials. STUDY DESIGN, SIZE, DURATION: An interdisciplinary workshop was held, involving representatives of both professional societies and experts from the European Union Eurogentest2 Coordination Action Project. PARTICIPANTS/MATERIALS, SETTING, METHODS: In March 2012, a group of experts from the European Society of Human Genetics, the European Society of Human Reproduction and Embryology and the EuroGentest2 Coordination Action Project met to discuss developments at the interface between clinical genetics and ART. MAIN RESULTS AND THE ROLE OF CHANCE: As more genetic causes of reproductive failure are now recognized and an increasing number of patients undergo testing of their genome prior to conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and PGD may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from RCTs to substantiate that the technique is both effective and efficient. Whole genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo. LIMITATIONS, REASONS FOR CAUTION: The legal landscape regarding assisted reproduction is evolving, but still remains very heterogeneous and often contradictory. The lack of legal harmonization and uneven access to infertility treatment and PGD/PGS fosters considerable cross-border reproductive care in Europe, and beyond. WIDER IMPLICATIONS OF THE FINDINGS: This continually evolving field requires communication between the clinical genetics and IVF teams and patients to ensure that they are fully informed and can make well-considered choices. STUDY FUNDING/COMPETING INTERESTS: Funding was received from ESHRE, ESHG and EuroGentest2 European Union Coordination Action project (FP7 - HEALTH-F4-2010-26146) to support attendance at this meeting.

Center for Medical Genetics Vrije Universiteit Brussel Brussels Belgium

Centre for Human Genetics Catholic University of Leuven Leuven Belgium

Department of Biology and Medical Genetics Charles University 2 Faculty of Medicine and University Hospital Motol Prague Czech Republic

Department of Clinical Genetics EMGO Institute for Health and Care Research VU University Medical Center Amsterdam The Netherlands

Department of Embryology and Genetics Vrije Universiteit Brussel Brussels Belgium

Department of Genetics and Cell Biology Research Institute GROW Faculty of Health Medicine and Life Sciences Maastricht University Maastricht The Netherlands

Department of Health Ethics and Society Research Institute GROW Faculty of Health Medicine and Life Sciences Maastricht University Maastricht The Netherlands

Department of Molecular Diagnostics Synlab Lausanne Switzerland

Department of Public Health and Primary Care KU Leuven Leuven Belgium

ICBAS Instituto de Ciências Biomédicas Abel Salazar and IBMC Institute for Molecular and Cell Biology University of Porto Porto Portugal

Institute of Genetics and Molecular and Cellular Biology UMR 1704 Illkirch France

National Institute for Health and Welfare Helsinki Finland

Reproductive Medicine Service Institut Universitari Dexeus Barcelona Spain

Reproductive Medicine Unit Institute for Women's Health University College London London UK

S 1 S Me R Reproductive Medicine Unit Bologna Italy

SAGBAL Hospital 'Dr Shterev' MC 'Reproductive Health' Sofia Bulgaria

School of Biosciences University of Kent Canterbury UK

School of Nursing and Midwifery Faculty of Health Education and Society Plymouth University Plymouth UK

UCL Centre for PG and D Institute for Womens Health University College London London UK Centre for Reproductive and Genetic Health London UK

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15023269
003      
CZ-PrNML
005      
20150730103443.0
007      
ta
008      
150709s2014 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/humrep/deu130 $2 doi
035    __
$a (PubMed)25006203
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Harper, Joyce $u UCL Centre for PG&D, Institute for Womens Health, University College London, London, UK Centre for Reproductive and Genetic Health, London, UK joyce.harper@ucl.ac.uk.
245    10
$a Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy / $c J. Harper, J. Geraedts, P. Borry, MC. Cornel, WJ. Dondorp, L. Gianaroli, G. Harton, T. Milachich, H. Kääriäinen, I. Liebaers, M. Morris, J. Sequeiros, K. Sermon, F. Shenfield, H. Skirton, S. Soini, C. Spits, A. Veiga, JR. Vermeesch, S. Viville, G. de Wert, M. Macek, . ,
520    9_
$a STUDY QUESTION: How has the interface between genetics and assisted reproduction technology (ART) evolved since 2005? SUMMARY ANSWER: The interface between ART and genetics has become more entwined as we increase our understanding about the genetics of infertility and we are able to perform more comprehensive genetic testing. WHAT IS KNOWN ALREADY: In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and ART and published an extended background paper, recommendations and two Editorials. STUDY DESIGN, SIZE, DURATION: An interdisciplinary workshop was held, involving representatives of both professional societies and experts from the European Union Eurogentest2 Coordination Action Project. PARTICIPANTS/MATERIALS, SETTING, METHODS: In March 2012, a group of experts from the European Society of Human Genetics, the European Society of Human Reproduction and Embryology and the EuroGentest2 Coordination Action Project met to discuss developments at the interface between clinical genetics and ART. MAIN RESULTS AND THE ROLE OF CHANCE: As more genetic causes of reproductive failure are now recognized and an increasing number of patients undergo testing of their genome prior to conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and PGD may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from RCTs to substantiate that the technique is both effective and efficient. Whole genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo. LIMITATIONS, REASONS FOR CAUTION: The legal landscape regarding assisted reproduction is evolving, but still remains very heterogeneous and often contradictory. The lack of legal harmonization and uneven access to infertility treatment and PGD/PGS fosters considerable cross-border reproductive care in Europe, and beyond. WIDER IMPLICATIONS OF THE FINDINGS: This continually evolving field requires communication between the clinical genetics and IVF teams and patients to ensure that they are fully informed and can make well-considered choices. STUDY FUNDING/COMPETING INTERESTS: Funding was received from ESHRE, ESHG and EuroGentest2 European Union Coordination Action project (FP7 - HEALTH-F4-2010-26146) to support attendance at this meeting.
650    _2
$a akreditace $7 D000068
650    _2
$a embryonální kmenové buňky $7 D053595
650    _2
$a epigenomika $7 D057890
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lékařská genetika $x etika $x zákonodárství a právo $x trendy $7 D005826
650    _2
$a nestabilita genomu $7 D042822
650    _2
$a dostupnost zdravotnických služeb $7 D006297
650    _2
$a lidé $7 D006801
650    _2
$a ženská infertilita $x genetika $7 D007247
650    _2
$a mužská infertilita $x genetika $7 D007248
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a zdravotní turistika $x trendy $7 D057193
650    _2
$a preimplantační diagnóza $x etika $x trendy $7 D019836
650    _2
$a reprodukční lékařství $x etika $x zákonodárství a právo $x trendy $7 D018456
650    _2
$a asistovaná reprodukce $x škodlivé účinky $x etika $x zákonodárství a právo $x trendy $7 D027724
650    _2
$a společnosti lékařské $7 D012955
651    _2
$a Evropa $7 D005060
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Geraedts, Joep $u Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
700    1_
$a Borry, Pascal $u Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
700    1_
$a Cornel, Martina C $u Department of Clinical Genetics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
700    1_
$a Dondorp, Wybo J $u Department of Health, Ethics & Society, Research Institute GROW, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
700    1_
$a Gianaroli, Luca $u S.I.S.Me.R., Reproductive Medicine Unit, Bologna, Italy.
700    1_
$a Harton, Gary $u School of Biosciences, University of Kent, Canterbury, UK (formerly Reprogenetics, Livingston, NJ, USA).
700    1_
$a Milachich, Tanya $u SAGBAL Hospital 'Dr. Shterev', MC 'Reproductive Health', Sofia, Bulgaria.
700    1_
$a Kääriäinen, Helena $u National Institute for Health and Welfare (THL), Helsinki, Finland.
700    1_
$a Liebaers, Inge $u Center for Medical Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
700    1_
$a Morris, Michael $u Department of Molecular Diagnostics, Synlab, Lausanne, Switzerland.
700    1_
$a Sequeiros, Jorge $u ICBAS - Instituto de Ciências Biomédicas Abel Salazar and IBMC - Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
700    1_
$a Sermon, Karen $u Department of Embryology and Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
700    1_
$a Shenfield, Françoise $u Reproductive Medicine Unit, Institute for Women's Health, University College London, London, UK.
700    1_
$a Skirton, Heather $u School of Nursing and Midwifery, Faculty of Health, Education and Society Plymouth University, Plymouth, UK.
700    1_
$a Soini, Sirpa $u National Institute for Health and Welfare (THL), Helsinki, Finland.
700    1_
$a Spits, Claudia $u Department of Embryology and Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
700    1_
$a Veiga, Anna $u Reproductive Medicine Service, Institut Universitari Dexeus, Barcelona, Spain.
700    1_
$a Vermeesch, Joris Robert $u Centre for Human Genetics, Catholic University of Leuven, Leuven, Belgium.
700    1_
$a Viville, Stéphane $u Institute of Genetics and Molecular and Cellular Biology (IGBMC), Centre National de Recherche Scientifique (CNRS) UMR 1704, Illkirch, France.
700    1_
$a de Wert, Guido $u Department of Health, Ethics & Society, Research Institute GROW, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
700    1_
$a Macek, Milan $u Department of Biology and Medical Genetics, Charles University-2 Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
700    1_
$a ,
773    0_
$w MED00002081 $t Human reproduction (Oxford, England) $x 1460-2350 $g Roč. 29, č. 8 (2014), s. 1603-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25006203 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150709 $b ABA008
991    __
$a 20150730103531 $b ABA008
999    __
$a ok $b bmc $g 1083607 $s 906262
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 29 $c 8 $d 1603-9 $i 1460-2350 $m Human reproduction $n Hum. reprod. (Oxf., Print) $x MED00002081
LZP    __
$a Pubmed-20150709

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace