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The effect of environmental chemicals on the tumor microenvironment
SC. Casey, M. Vaccari, F. Al-Mulla, R. Al-Temaimi, A. Amedei, MH. Barcellos-Hoff, DG. Brown, M. Chapellier, J. Christopher, CS. Curran, S. Forte, RA. Hamid, P. Heneberg, DC. Koch, PK. Krishnakumar, E. Laconi, V. Maguer-Satta, F. Marongiu, L....
Language English Country England, Great Britain
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 1996 to 1 year ago
Open Access Digital Library
from 1996-01-01
Medline Complete (EBSCOhost)
from 1996-01-01 to 1 year ago
PubMed
26106136
DOI
10.1093/carcin/bgv035
Knihovny.cz E-resources
- MeSH
- Carcinogenesis chemically induced MeSH
- Humans MeSH
- Tumor Microenvironment drug effects MeSH
- Neoplasms chemically induced MeSH
- Hazardous Substances adverse effects MeSH
- Environmental Exposure adverse effects MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through effects on epithelial cells, the most common origin of cancer, as well as on stromal cells, extracellular matrix components and immune cells. Here, we review how environmental exposures can perturb the tumor microenvironment. We suggest a role for disrupting chemicals such as nickel chloride, Bisphenol A, butyltins, methylmercury and paraquat as well as more traditional carcinogens, such as radiation, and pharmaceuticals, such as diabetes medications, in the disruption of the tumor microenvironment. Further studies interrogating the role of chemicals and their mixtures in dose-dependent effects on the tumor microenvironment could have important general mechanistic implications for the etiology and prevention of tumorigenesis.
Cancer Research UK Cambridge Institute University of Cambridge Robinson Way CB2 0RE Cambridge UK
Center for Experimental Molecular Medicine Meibergdreef 9 1105 AZ Amsterdam The Netherlands
Centre De Recherche En Cancerologie De Lyon U1052 UMR5286 Université de Lyon 69007 Lyon France
Charles University Prague 3rd Faculty of Medicine 100 00 Prague 10 Czech Republic
Department of Experimental and Clinical Medicine University of Firenze 50134 Florence Italy
Department of Medicine University of Louisville Louisville KY 40202 USA
Department of Pathology Kuwait University 13110 Safat Kuwait
Department of Radiation Oncology NYU School of Medicine New York NY 10016 USA
Department of Science and Biomedical Technology University of Cagliari 09124 Cagliari Italy
Division of Oncology Departments of Medicine and Pathology Stanford University Stanford CA 94305 USA
Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang 43400 Selangor Malaysia
Institute of Molecular Genetics National Research Council 27100 Pavia Italy
Mediterranean Institute of Oncology 95029 Viagrande Italy
Pathology Unit Mediterranean Institute of Oncology 95029 Viagrande Italy
School of Medicine and Public Health University of Wisconsin Madison Madison WI 53705 USA
University of Pennsylvania School of Medicine Philadelphia PA 19104 USA
Urology Department Kasr Al Ainy School of Medicine Cairo University El Manial Cairo 11562 Egypt
References provided by Crossref.org
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- $a The effect of environmental chemicals on the tumor microenvironment / $c SC. Casey, M. Vaccari, F. Al-Mulla, R. Al-Temaimi, A. Amedei, MH. Barcellos-Hoff, DG. Brown, M. Chapellier, J. Christopher, CS. Curran, S. Forte, RA. Hamid, P. Heneberg, DC. Koch, PK. Krishnakumar, E. Laconi, V. Maguer-Satta, F. Marongiu, L. Memeo, C. Mondello, J. Raju, J. Roman, R. Roy, EP. Ryan, S. Ryeom, HK. Salem, AI. Scovassi, N. Singh, L. Soucek, L. Vermeulen, JR. Whitfield, J. Woodrick, A. Colacci, WH. Bisson, DW. Felsher,
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