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Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer in the Real-World Setting in Central Europe: The INSIGHT Study

R. Ramlau, T. Cufer, P. Berzinec, R. Dziadziuszko, W. Olszewski, H. Popper, P. Bajcic, L. Dušek, Z. Zbozinkova, R. Pirker, . ,

. 2015 ; 10 (9) : 1370-4.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16020369

The ImplementatioN of perSonalized medicine In NSCLC in Central Europe: EGFR testing, Histopathology, and clinical feaTures (INSIGHT) observational study assessed both implementation of epidermal growth factor receptor (EGFR) mutation testing and treatment of patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC) in a real-world setting in Central Europe. A total of 1785 patients from 14 cancer centers of six Central European countries were enrolled. EGFR mutations were detected in tumors of 13.8% of the patients. More than 70% of patients with advanced EGFR mutation-positive NSCLC received EGFR tyrosine kinase inhibitors as first-line therapy. The INSIGHT study demonstrated the establishment of EGFR mutation testing, a mutation rate consistent with other Caucasian patients populations, and adherence to current guidelines regarding treatment of patients with EGFR mutation-positive tumors in Central Europe.

Citace poskytuje Crossref.org

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$a Ramlau, Rodryg $u *Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland; †University Clinic, Golnik, Slovenia; ‡Specialized Hospital of St Zoerardus Zobor, Nitra, Slovakia; §Medical University of Gdansk, Gdansk, ‖The Maria Sklodowska-Curie Institute of Oncology, Warsaw, Poland; **Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic; ¶Medical University of Graz, Graz, #Boehringer Ingelheim RCV, Vienna, and ††Department of Medicine I, Medical University of Vienna, Vienna, Austria.
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