Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits

L. Sulovska, D. Holub, Z. Zidova, M. Divoka, M. Hajduch, V. Mihal, J. Vrbkova, M. Horvathova, D. Pospisilova

. 2016 ; 160 (2) : 231-237. [pub] 20151027

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17012982

Grantová podpora
NT13587 MZ0 CEP - Centrální evidence projektů

BACKGROUND AND AIMS: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits. METHODS: Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits. RESULTS: The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR. CONCLUSION: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17012982
003      
CZ-PrNML
005      
20190919082747.0
007      
ta
008      
170413s2016 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2015.054 $2 doi
035    __
$a (PubMed)26592557
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Sulovská, Lucie $u Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic $7 xx0144823
245    10
$a Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits / $c L. Sulovska, D. Holub, Z. Zidova, M. Divoka, M. Hajduch, V. Mihal, J. Vrbkova, M. Horvathova, D. Pospisilova
520    9_
$a BACKGROUND AND AIMS: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits. METHODS: Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits. RESULTS: The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR. CONCLUSION: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease.
650    _2
$a mladiství $7 D000293
650    _2
$a analýza rozptylu $7 D000704
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a dědičná eliptocytóza $x krev $7 D004612
650    _2
$a erytrocytární membrána $x metabolismus $7 D004910
650    _2
$a erytropoéza $x fyziologie $7 D004920
650    _2
$a hemostáza $x fyziologie $7 D006487
650    _2
$a hepcidiny $x metabolismus $7 D064451
650    _2
$a lidé $7 D006801
650    _2
$a železo $x metabolismus $7 D007501
650    _2
$a dědičná sférocytóza $x krev $7 D013103
650    _2
$a talasemie $x metabolismus $7 D013789
655    _2
$a časopisecké články $7 D016428
700    1_
$a Holub, Dušan $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic $7 xx0169439
700    1_
$a Židová, Zuzana $u Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic $7 xx0207826
700    1_
$a Divoká, Martina $u Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic $7 xx0066076
700    1_
$a Hajdúch, Marián $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic $7 xx0050218
700    1_
$a Mihál, Vladimír, $u Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic $d 1951- $7 nlk19990073561
700    1_
$a Vrbková, J. $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic $7 _AN085567
700    1_
$a Horváthová, Monika $u Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic $7 ntk2011644397
700    1_
$a Pospíšilová, Dagmar $u Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic $7 xx0052603
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 160, č. 2 (2016), s. 231-237
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20190919083138 $b ABA008
999    __
$a ok $b bmc $g 1205378 $s 973755
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 160 $c 2 $d 231-237 $e 20151027 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
GRA    __
$a NT13587 $p MZ0
LZP    __
$b NLK118 $a Pubmed-20170413

Najít záznam

Citační ukazatele

Možnosti archivace