Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways

A. De Luca, M. Pariano, B. Cellini, C. Costantini, VR. Villella, SS. Jose, M. Palmieri, M. Borghi, C. Galosi, G. Paolicelli, L. Maiuri, J. Fric, T. Zelante,

. 2017 ; 20 (7) : 1667-1680.

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18024731

The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway inflammation in models of infection and allergy. Signaling through IL-17RA was required for efficient microbial clearance and prevention of allergy; in the absence of IL-17RA, signaling through IL-17RC on epithelial cells, predominantly by IL-17F, significantly exacerbated lower airway Aspergillus or Pseudomonas infection and allergic airway inflammation. In contrast, following infection with the upper respiratory pathogen Staphylococcus aureus, the IL-17F/IL-17RC axis mediated protection. Thus, IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract in particular, and should be investigated further as a therapeutic target for treating pathological inflammation in the lung.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18024731
003      
CZ-PrNML
005      
20180711105730.0
007      
ta
008      
180709s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.celrep.2017.07.063 $2 doi
035    __
$a (PubMed)28813677
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a De Luca, Antonella $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
245    14
$a The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways / $c A. De Luca, M. Pariano, B. Cellini, C. Costantini, VR. Villella, SS. Jose, M. Palmieri, M. Borghi, C. Galosi, G. Paolicelli, L. Maiuri, J. Fric, T. Zelante,
520    9_
$a The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway inflammation in models of infection and allergy. Signaling through IL-17RA was required for efficient microbial clearance and prevention of allergy; in the absence of IL-17RA, signaling through IL-17RC on epithelial cells, predominantly by IL-17F, significantly exacerbated lower airway Aspergillus or Pseudomonas infection and allergic airway inflammation. In contrast, following infection with the upper respiratory pathogen Staphylococcus aureus, the IL-17F/IL-17RC axis mediated protection. Thus, IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract in particular, and should be investigated further as a therapeutic target for treating pathological inflammation in the lung.
650    _2
$a zvířata $7 D000818
650    _2
$a aspergilóza $x genetika $x imunologie $x mikrobiologie $x patologie $7 D001228
650    _2
$a Aspergillus $x imunologie $7 D001230
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a náchylnost k nemoci $7 D004198
650    _2
$a epitelové buňky $x imunologie $x mikrobiologie $x patologie $7 D004847
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a regulace genové exprese $7 D005786
650    _2
$a lidé $7 D006801
650    _2
$a alergie $x genetika $x imunologie $x mikrobiologie $x patologie $7 D006967
650    _2
$a interleukin-17 $x nedostatek $x genetika $x imunologie $7 D020381
650    _2
$a plíce $x imunologie $x mikrobiologie $x patologie $7 D008168
650    _2
$a myši $7 D051379
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a myši knockoutované $7 D018345
650    _2
$a protein - isoformy $x nedostatek $x genetika $x imunologie $7 D020033
650    _2
$a Pseudomonas $x imunologie $7 D011549
650    _2
$a pseudomonádové infekce $x genetika $x imunologie $x mikrobiologie $x patologie $7 D011552
650    _2
$a receptory interleukinu-17 $x nedostatek $x genetika $x imunologie $7 D053722
650    _2
$a respirační sliznice $x imunologie $x mikrobiologie $x patologie $7 D020545
650    _2
$a signální transdukce $7 D015398
650    _2
$a stafylokokové infekce $x genetika $x imunologie $x mikrobiologie $x patologie $7 D013203
650    _2
$a Staphylococcus aureus $x imunologie $7 D013211
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pariano, Marilena $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Cellini, Barbara $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Costantini, Claudio $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Villella, Valeria Rachela $u European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy.
700    1_
$a Jose, Shyam Sushama $u Center for Translational Medicine, International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic.
700    1_
$a Palmieri, Melissa $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Borghi, Monica $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Galosi, Claudia $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Paolicelli, Giuseppe $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
700    1_
$a Maiuri, Luigi $u European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
700    1_
$a Fric, Jan $u Center for Translational Medicine, International Clinical Research Center, St. Anne's University Hospital Brno, Czech Republic.
700    1_
$a Zelante, Teresa $u Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. Electronic address: teresa.zelante@unipg.it.
773    0_
$w MED00188029 $t Cell reports $x 2211-1247 $g Roč. 20, č. 7 (2017), s. 1667-1680
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28813677 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180711110021 $b ABA008
999    __
$a ok $b bmc $g 1316862 $s 1021652
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 20 $c 7 $d 1667-1680 $i 2211-1247 $m Cell reports $n Cell Rep $x MED00188029
LZP    __
$a Pubmed-20180709

Find record

Citation metrics

Archiving options