-
Je něco špatně v tomto záznamu ?
Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use
J. Salát, P. Formanová, M. Huňady, L. Eyer, M. Palus, D. Ruzek,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2002-01-01 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest)
od 2002-01-01 do Před 2 měsíci
Family Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest)
od 2002-01-01 do Před 2 měsíci
- MeSH
- buněčné kultury MeSH
- formaldehyd farmakologie MeSH
- imunogenicita vakcíny MeSH
- inaktivované vakcíny aplikace a dávkování imunologie MeSH
- klíšťová encefalitida prevence a kontrola veterinární MeSH
- laktace MeSH
- mléko virologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- neutralizující protilátky krev imunologie MeSH
- ovce MeSH
- polymerázová řetězová reakce MeSH
- protilátky virové krev imunologie MeSH
- RNA virová analýza krev MeSH
- virové vakcíny aplikace a dávkování imunologie MeSH
- viry klíšťové encefalitidy MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In tick-borne encephalitis (TBE) endemic areas, consumption of unpasteurized milk or milk products from grazing domestic ruminants (goats, cattle, and sheep) represents a risk of TBE virus (TBEV) infection for humans. In addition to vaccination of humans, human alimentary TBEV infections can be avoided by pasteurizing milk or by vaccination of the ruminants. However, there is presently no TBEV vaccine for veterinary use. Here, we developed a new veterinary TBE vaccine candidate based on cell culture-derived, purified, and formaldehyde-inactivated TBEV (strain Hypr). The safety and immunogenicity of the vaccine was evaluated in mice and sheep and was well-tolerated while eliciting the production of high levels of virus-neutralizing antibodies. Vaccination provided full protection against lethal TBE in mice, prevented development of viremia in sheep and presence of TBEV in milk of lactating ewes. This vaccine is a good candidate for immunization of ruminants to prevent alimentary milk-borne TBEV infections in humans.
Bioveta Inc Ivanovice na Hane Czech Republic
Department of Virology Veterinary Research Institute Brno Czech Republic
Institute of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19028145
- 003
- CZ-PrNML
- 005
- 20230808135244.0
- 007
- ta
- 008
- 190813s2018 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.vaccine.2018.10.034 $2 doi
- 035 __
- $a (PubMed)30337175
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Salát, Jiří $u Department of Virology, Veterinary Research Institute, Brno, Czech Republic. Electronic address: salat@vri.cz.
- 245 10
- $a Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use / $c J. Salát, P. Formanová, M. Huňady, L. Eyer, M. Palus, D. Ruzek,
- 520 9_
- $a In tick-borne encephalitis (TBE) endemic areas, consumption of unpasteurized milk or milk products from grazing domestic ruminants (goats, cattle, and sheep) represents a risk of TBE virus (TBEV) infection for humans. In addition to vaccination of humans, human alimentary TBEV infections can be avoided by pasteurizing milk or by vaccination of the ruminants. However, there is presently no TBEV vaccine for veterinary use. Here, we developed a new veterinary TBE vaccine candidate based on cell culture-derived, purified, and formaldehyde-inactivated TBEV (strain Hypr). The safety and immunogenicity of the vaccine was evaluated in mice and sheep and was well-tolerated while eliciting the production of high levels of virus-neutralizing antibodies. Vaccination provided full protection against lethal TBE in mice, prevented development of viremia in sheep and presence of TBEV in milk of lactating ewes. This vaccine is a good candidate for immunization of ruminants to prevent alimentary milk-borne TBEV infections in humans.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a neutralizující protilátky $x krev $x imunologie $7 D057134
- 650 _2
- $a protilátky virové $x krev $x imunologie $7 D000914
- 650 _2
- $a buněčné kultury $7 D018929
- 650 _2
- $a viry klíšťové encefalitidy $7 D004669
- 650 _2
- $a klíšťová encefalitida $x prevence a kontrola $x veterinární $7 D004675
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a formaldehyd $x farmakologie $7 D005557
- 650 _2
- $a imunogenicita vakcíny $7 D000071497
- 650 _2
- $a laktace $7 D007774
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši inbrední BALB C $7 D008807
- 650 _2
- $a mléko $x virologie $7 D008892
- 650 _2
- $a polymerázová řetězová reakce $7 D016133
- 650 _2
- $a RNA virová $x analýza $x krev $7 D012367
- 650 _2
- $a ovce $7 D012756
- 650 _2
- $a inaktivované vakcíny $x aplikace a dávkování $x imunologie $7 D015164
- 650 _2
- $a virové vakcíny $x aplikace a dávkování $x imunologie $7 D014765
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Pokorná, Petra $u Department of Virology, Veterinary Research Institute, Brno, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. $7 mzk2018988134
- 700 1_
- $a Huňady, Milan $u Bioveta, Inc., Ivanovice na Hane, Czech Republic.
- 700 1_
- $a Eyer, Luděk $u Department of Virology, Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic. $7 xx0098551
- 700 1_
- $a Palus, Martin $u Department of Virology, Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
- 700 1_
- $a Růžek, Daniel, $u Department of Virology, Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic. Electronic address: ruzekd@paru.cas.cz. $d 1981- $7 stk2008441707
- 773 0_
- $w MED00004631 $t Vaccine $x 1873-2518 $g Roč. 36, č. 48 (2018), s. 7257-7261
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30337175 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190813 $b ABA008
- 991 __
- $a 20230808135241 $b ABA008
- 999 __
- $a ok $b bmc $g 1433294 $s 1066605
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 36 $c 48 $d 7257-7261 $e 20181015 $i 1873-2518 $m Vaccine $n Vaccine $x MED00004631
- LZP __
- $a Pubmed-20190813
