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The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants
E. Marzetti, M. Cesari, R. Calvani, J. Msihid, M. Tosato, L. Rodriguez-Mañas, F. Lattanzio, A. Cherubini, R. Bejuit, M. Di Bari, M. Maggio, B. Vellas, T. Dantoine, AJ. Cruz-Jentoft, CC. Sieber, E. Freiberger, A. Skalska, T. Grodzicki, AJ....
Language English Country England, Great Britain
Document type Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Cost-Benefit Analysis MeSH
- Exercise * MeSH
- Frail Elderly * MeSH
- Quality of Life MeSH
- Humans MeSH
- Mobility Limitation * MeSH
- Disability Evaluation MeSH
- Sarcopenia prevention & control therapy MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging MeSH
- Accidental Falls prevention & control MeSH
- Patient Selection * MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial, Phase III MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Geographicals
- Italy MeSH
BACKGROUND: The ongoing "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)" randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. METHODS: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick "participant profiling" questionnaire was devised to facilitate PF&S case finding. RESULTS: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. CONCLUSION: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.
Department of Clinical Sciences and Community Health University of Milan Italy
Department of Geriatric Rehabilitation University Hospital of Parma Parma Italy
Department of Geriatrics 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Internal Medicine Medical University of Graz Graz Austria
Department of Medicine and Surgery University of Parma Parma Italy
Foundation for Diabetes Research in Older People Diabetes Frail Limited Worcestershire UK
Geriatria Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento IRCCS INRCA Ancona Italy
Geriatric Department Silesians Hospital Opava Czech Republic
Geriatric Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Gérontopôle University Hospital of Toulouse Toulouse France
Helsinki University Hospital Medicine and Rehabilitation Helsinki Finland
Institute for Biomedicine of Aging Friedrich Alexander University Nuremberg Germany
Sanofi R and D Chilly Mazarin Paris France
Scientific Direction IRCCS INRCA Ancona Italy
Service of Geriatrics Getafe University Hospital Madrid Spain
Servicio de Geriatría Hospital Universitario Ramón y Cajal Madrid Spain
Translational Medicine Novartis Institutes for Biomedical Research Basel Switzerland
University Hospital of Limoges Limoges France
University of Helsinki Clinicum Helsinki Finland
University of Oulu Center for Life Course Health Research Oulu Finland
References provided by Crossref.org
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