Background:Research in telerehabilitation (TR) in neurology tends to focus on patients with low to moderate disability. For neurology patients with severe mobility limitations, TR can help to enable rehabilitation for people whose mobility limitations make it difficult for them to access rehabilitation facilities. The aim of this study is to evaluate the interest of people with neurological disability caused by multiple sclerosis (MS) in TR services.Methods:This electronic survey targeted individuals with MS, specifically those with a higher level of disability.Results:A total of 355 patients with MS (155 with severe disabilities) participated in this study. There was no difference in interest in rehabilitation between people with mild-to-moderate and severe disabilities (p = 0.1258, confidence interval [CI] = 95%). However, we found a higher interest in upper limb exercises (p = 0.0006, CI = 95%) and balance training (p = 0.0000, CI = 95%) among people with higher disability.Conclusion:The results of this study may help to improve the planning and targeting of TR interventions, where a different focus of intervention is appropriate for patients with different levels of disability. This may enable TR to be maximally tailored to patient capabilities and current greatest limitations. For example, for people with severe disabilities, it is appropriate to focus on training the upper limb function to maintain self-sufficiency and implement interventions to prevent falls.

• MeSH
• lidé MeSH
• omezení pohyblivosti MeSH
• roztroušená skleróza * rehabilitace   MeSH
• telerehabilitace * metody   MeSH
• terapie cvičením metody   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

Introduction: Objective of this study is to describe impact of gender, age, social status, and geographic location on mobility changes during the COVID-19 pandemic within the Czechia, Hradec Kralove region, and Ostrava region.Methods: A cross-sectional study was carried out in two regions in the Czechia: the Hradec Kralove region and the Ostrava region.Results: The age group of seniors 85 and older was more vulnerable to these alterations than other age groups. Age had a statistically significant impact on both the frequency of trips and the mode of transportation used. Seniors' shifts in mobility were more frequently impacted by urbanization, whereas the region's impact was seen in as many as five components. Transport, Route, and Time all showed the impact of urbanization. However, the region had the largest impact.Conclusion: There has been little evidence of the influence of age, gender, or social class on perceptions of changes during COVID-19. Research found conflicting evidence about older adults' physical activity throughout the epidemic.

• MeSH
• COVID-19 * MeSH
• doprava MeSH
• lidé MeSH
• omezení pohyblivosti MeSH
• průzkumy a dotazníky MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sociální izolace * MeSH
• socioekonomické faktory MeSH
• Check Tag
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Geografické názvy
• Česká republika MeSH

BACKGROUND: Obesity leads to low-grade inflammation in the adipose tissue and liver and neuroinflammation in the brain. Obesity-induced insulin resistance (IR) and neuroinflammation seem to intensify neurodegeneration including Alzheimer's disease. In this study, the impact of high-fat (HF) diet-induced obesity on potential neuroinflammation and peripheral IR was tested separately in males and females of THY-Tau22 mice, a model of tau pathology expressing mutated human tau protein. METHODS: Three-, 7-, and 11-month-old THY-Tau22 and wild-type males and females were tested for mobility, anxiety-like behavior, and short-term spatial memory in open-field and Y-maze tests. Plasma insulin, free fatty acid, cholesterol, and leptin were evaluated with commercial assays. Liver was stained with hematoxylin and eosin for histology. Brain sections were 3',3'-diaminobenzidine (DAB) and/or fluorescently detected for ionized calcium-binding adapter molecule 1 (Iba1), glial fibrillary acidic protein (GFAP), and tau phosphorylated at T231 (pTau (T231)), and analyzed. Insulin signaling cascade, pTau, extracellular signal-regulated kinase 1/2 (ERK1/2), and protein phosphatase 2A (PP2A) were quantified by western blotting of hippocampi of 11-month-old mice. Data are mean ± SEM and were subjected to Mann-Whitney t test within age and sex and mixed-effects analysis and Bonferroni's post hoc test for age comparison. RESULTS: Increased age most potently decreased mobility and increased anxiety in all mice. THY-Tau22 males showed impaired short-term spatial memory. HF diet increased body, fat, and liver weights and peripheral IR. HF diet-fed THY-Tau22 males showed massive Iba1+ microgliosis and GFAP+ astrocytosis in the hippocampus and amygdala. Activated astrocytes colocalized with pTau (T231) in THY-Tau22, although no significant difference in hippocampal tau phosphorylation was observed between 11-month-old HF and standard diet-fed THY-Tau22 mice. Eleven-month-old THY-Tau22 females, but not males, on both diets showed decreased synaptic and postsynaptic plasticity. CONCLUSIONS: Significant sex differences in neurodegenerative signs were found in THY-Tau22. Impaired short-term spatial memory was observed in 11-month-old THY-tau22 males but not females, which corresponded to increased neuroinflammation colocalized with pTau(T231) in the hippocampi and amygdalae of THY-Tau22 males. A robust decrease in synaptic and postsynaptic plasticity was observed in 11-month-old females but not males. HF diet caused peripheral but not central IR in mice of both sexes.

• MeSH
• dieta s vysokým obsahem tuků škodlivé účinky   MeSH
• fosforylace MeSH
• hipokampus metabolismus   MeSH
• inzulinová rezistence * MeSH
• krátkodobá paměť MeSH
• modely nemocí na zvířatech MeSH
• mozek metabolismus   patofyziologie   MeSH
• myši inbrední C57BL MeSH
• myši transgenní MeSH
• myši MeSH
• obezita komplikace   etiologie   MeSH
• omezení pohyblivosti MeSH
• proteiny tau MeSH
• sexuální faktory MeSH
• stárnutí metabolismus   MeSH
• tauopatie komplikace   genetika   MeSH
• zánět MeSH
• ztučnělá játra metabolismus   patologie   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

OBJECTIVES: Treatment for progressive multiple sclerosis (pMS) is a key area of research. To date, whether MS type and the rehabilitation setting are associated with worse or better response to rehabilitation is unclear. We aimed to understand the association between balance and MS type, in/outpatient treatment and specificity of the intervention. METHODS: We assessed 150 people with MS before and after in/outpatient rehabilitation. The Berg Balance Scale (BBS) was used to discriminate between responders (≥+3-point improvement in BBS score; a clinically meaningful improvement) and non-responders to specific or non-specific balance rehabilitation. Factors associated with balance were analyzed by univariate and multivariable logistic regression analyses, estimating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Balance improved after rehabilitation: median (quartile 1 [Q1]-Q3) BBS score pre- and post-rehabilitation of 49 (45-53) and 52 (47-55) (P<0.001). Univariate logistic analysis revealed a clinically meaningful improvement in balance associated with pMS (OR 2.21 [95% CI 1.09-4.05]), inpatient therapy (0.41 [0.19-0.84]), using a walking aid (1.68 [1.06-2.69]), and low baseline BBS score (0.86 [0.81-0.92]). On multivariable analysis, probability of improvement was similar for participants with pMS and the relapsing-remitting form but was associated with low baseline BBS score and specific treatment (OR 0.81 [95% CI 0.74-0.89] and 5.66 [1.79-21.5]). CONCLUSION: A clinically meaningful improvement in balance was more likely when MS individuals with moderate to high disability had specific exercises targeting balance, but MS type did not influence the outcome.

• MeSH
• dospělí MeSH
• fyzioterapie (techniky) MeSH
• interval spolehlivosti MeSH
• lidé středního věku MeSH
• lidé MeSH
• logistické modely MeSH
• longitudinální studie MeSH
• odds ratio MeSH
• omezení pohyblivosti MeSH
• pacienti ambulantní MeSH
• pacienti hospitalizovaní MeSH
• poruchy senzitivity etiologie   terapie   MeSH
• posturální rovnováha * MeSH
• randomizované kontrolované studie jako téma statistika a číselné údaje   MeSH
• retrospektivní studie MeSH
• roztroušená skleróza komplikace   patofyziologie   rehabilitace   MeSH
• stupeň závažnosti nemoci MeSH
• úrazy pádem MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pragmatická klinická studie MeSH
• Geografické názvy
• Irsko MeSH
• Itálie MeSH

• MeSH
• astrocytom * chirurgie   diagnostické zobrazování   epidemiologie   farmakoterapie   klasifikace   patologie   terapie   MeSH
• diferenciální diagnóza MeSH
• dítě MeSH
• horní končetina patologie   MeSH
• kraniotomie MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• nádory mozkového kmene chirurgie   diagnostické zobrazování   epidemiologie   farmakoterapie   klasifikace   patologie   terapie   MeSH
• neurochirurgické výkony metody   MeSH
• omezení pohyblivosti MeSH
• paréza etiologie   MeSH
• progrese nemoci MeSH
• pronační poloha MeSH
• vinblastin aplikace a dávkování   MeSH
• výsledek terapie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

• Klíčová slova
• concorde position, resekce nádoru,
• MeSH
• dítě MeSH
• dysartrie etiologie   MeSH
• kraniotomie MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• meduloblastom * chirurgie   diagnostické zobrazování   epidemiologie   klasifikace   komplikace   patologie   terapie   MeSH
• neurochirurgické výkony MeSH
• omezení pohyblivosti MeSH
• prognóza MeSH
• tremor etiologie   MeSH
• věkové faktory MeSH
• výsledek terapie MeSH
• zadní jáma lební patologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

• Klíčová slova
• neurografie,
• MeSH
• alkoholická neuropatie * diagnóza   farmakoterapie   krev   MeSH
• ataxie chůze etiologie   farmakoterapie   MeSH
• diferenciální diagnóza MeSH
• dolní končetina patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory plic diagnóza   MeSH
• nedostatek vitaminu B12 diagnóza   farmakoterapie   krev   MeSH
• omezení pohyblivosti MeSH
• parestezie etiologie   MeSH
• svalová slabost etiologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

Kniha je určena studentům vysokých i středních škol, odborné veřejnosti i ostatním zájemcům o problematiku tvorby bezbariérově přístupné veřejné osobní dopravy a navazujícího prostředí. Kniha přináší poznatky aplikovatelné v procesu tvorby přístupného prostředí pozemních komunikací, zastávek veřejné dopravy, odbavovacích hal, železničních nástupišť, vozidel a informačních systémů podle platných právních a technických předpisů. Nakladatelská anotace. Kráceno

• Klíčová slova
• bezbariérový doprava,
• MeSH
• architektonická přístupnost normy   zákonodárství a právo   MeSH
• doprava normy   MeSH
• omezení pohyblivosti MeSH
• postižení MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Doprava
• NLK Obory
• zdravotně postižení

BACKGROUND: The ongoing "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)" randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describe the procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees. METHODS: The identification of PF&S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick "participant profiling" questionnaire was devised to facilitate PF&S case finding. RESULTS: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy. CONCLUSION: PF&S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.

• MeSH
• analýza nákladů a výnosů MeSH
• cvičení * MeSH
• křehký senior * MeSH
• kvalita života MeSH
• lidé MeSH
• omezení pohyblivosti * MeSH
• posuzování pracovní neschopnosti MeSH
• sarkopenie prevence a kontrola   terapie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• stárnutí MeSH
• úrazy pádem prevence a kontrola   MeSH
• výběr pacientů * MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze III MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• randomizované kontrolované studie MeSH
• Geografické názvy
• Itálie MeSH

BACKGROUND: This paper provides a first comparative exploratory analysis of our findings from DEMDATA, a collaborative project between Austria and the Czech Republic. Analysed here are data from the residents and the environment assessment protocol. METHODS: In a cross sectional study design, residents from randomly drawn and stratified nursing homes were investigated using a common study protocol. RESULTS: From a total resident pool of 1666 persons, 1085 (571 in Austria, 514 in the Czech Republic) persons signed a consent form and participated in the data collection. More than 70% of residents assessed were female and the population was on average 85 years old. A discrepancy between the presence of a medical diagnosis in the charts of the residents and the results of cognitive testing was found. In Austria, 85.2%, in the Czech Republic 53.0% of residents had cognitive impairment. In Austria 80.0%, and in the Czech Republic 56.7% had behavioural problems. With respect to pain, 44.8% in Austria, and 51.5% in the Czech Republic had mild to severe pain. 78.4% of Austrian and 74.5% of the residents had problems with mobility and both populations were in danger of malnutrition. CONCLUSIONS: Most of the prevalence rates are comparable with previous studies also using direct resident assessment. Variations in prevalence rates seem to result mainly from the assessment technique (direct cognitive testing vs. medical chart review). The high prevalence rates for dementia, behavioural symptoms, pain and malnutrition indicate an immediate call for attention to further research and practice development.

• MeSH
• behaviorální symptomy diagnóza   epidemiologie   MeSH
• bolest diagnóza   epidemiologie   MeSH
• demence diagnóza   epidemiologie   MeSH
• domovy pro seniory trendy   MeSH
• kognitivní dysfunkce diagnóza   epidemiologie   MeSH
• lidé MeSH
• náhodné rozdělení MeSH
• omezení pohyblivosti * MeSH
• pečovatelské domovy trendy   MeSH
• prevalence MeSH
• průřezové studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Rakousko MeSH