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In silico validation of the Autoinflammatory Disease Damage Index
NM. Ter Haar, ALJ. van Delft, KV. Annink, H. van Stel, SM. Al-Mayouf, G. Amaryan, J. Anton, KS. Barron, S. Benseler, PA. Brogan, L. Cantarini, M. Cattalini, AV. Cochino, F. de Benedetti, F. Dedeoglu, AA. de Jesus, E. Demirkaya, P. Dolezalova, KL....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, validační studie
NLK
ProQuest Central
od 1939-01-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1939-01-01 do Před 6 měsíci
Family Health Database (ProQuest)
od 1939-01-01 do Před 6 měsíci
- MeSH
- dědičné zánětlivé autoimunitní nemoci komplikace diagnóza MeSH
- dítě MeSH
- dospělí MeSH
- familiární středomořská horečka komplikace diagnóza MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nedostatek mevalonátkinázy komplikace diagnóza MeSH
- odchylka pozorovatele MeSH
- periodické syndromy asociované s kryopyrinem komplikace diagnóza MeSH
- počítačová simulace MeSH
- registrace MeSH
- reprodukovatelnost výsledků MeSH
- stupeň závažnosti nemoci * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- validační studie MeSH
INTRODUCTION: Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting. METHODS: The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha. RESULTS: The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items. CONCLUSION: The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.
4th Department of Pediatrics Aristotle University of Thessaloniki Thessaloniki Greece
Autoinflammatory Alliance San Francisco California USA
Département de Médecine Interne et Immunologie Clinique Université de Lille Lille France
Department of Paediatric Rheumatology AOUG Martino Messina Italy
Department of Paediatrics Meir Medical Centre Kfar Saba Israel
Department of Paediatrics University of California San Diego California USA
Department of Pediatrics King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia
Departmentof Paediatrics Aarhus University Hospital Aarhus Denmark
Departments of Paediatrics and Rheumatology Alberta Children's Hospital Calgary Alberta Canada
Dipartimento di Medicina Pediatrica IRCCS Ospedale Pediatrico Bambino Gesù Roma Italy
Direzione Scientifica Istituto Giannina Gaslini Genova Liguria Italy
Division of Medicine University College London London UK
Division of Rheumatology Ospedale Pediatrico Bambino Gesù Rome Italy
Inflammatory Disease Section National Human Genome Research Institute Bethesda Maryland USA
Institution Università degli Studi di Genova and G Gaslini Institute Genova Italy
Paediatric Clinic University of Brescia and Spedali Civili di Brescia Brescia Italy
Paediatric Rheumatology Unit 4272 Rigshospitalet Copenhagen Denmark
Paediatric Rheumatology Unit Hospital Sant Joan de Déu Barcelona Spain
Pediatric Rheumatology Hacettepe University Ankara Turkey
Reference Centre for Autoinflammatory Diseases Versailles Hospital Le Chesnay France
Servicio de Inmunología Reumatología Hospital de Pediatria Juan P Garrahan Buenos Aires Argentina
Translational Autoinflammatory Disease Section NIAMS NIH Bethesda Maryland USA
Western University Children's Hospital London Health Sciences Centre London UK
Citace poskytuje Crossref.org
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- $a Ter Haar, Nienke M $u Laboratory for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands. Department of Paediatric Immunology and Rheumatology, University Medical Centre Utrecht, Utrecht, The Netherlands.
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- $a In silico validation of the Autoinflammatory Disease Damage Index / $c NM. Ter Haar, ALJ. van Delft, KV. Annink, H. van Stel, SM. Al-Mayouf, G. Amaryan, J. Anton, KS. Barron, S. Benseler, PA. Brogan, L. Cantarini, M. Cattalini, AV. Cochino, F. de Benedetti, F. Dedeoglu, AA. de Jesus, E. Demirkaya, P. Dolezalova, KL. Durrant, G. Fabio, R. Gallizzi, R. Goldbach-Mansky, E. Hachulla, V. Hentgen, T. Herlin, M. Hofer, HM. Hoffman, A. Insalaco, AF. Jansson, T. Kallinich, I. Kone-Paut, A. Kozlova, JB. Kuemmerle-Deschner, HJ. Lachmann, RM. Laxer, A. Martini, S. Nielsen, I. Nikishina, AK. Ombrello, S. Özen, E. Papadopoulou-Alataki, P. Quartier, D. Rigante, R. Russo, A. Simon, M. Trachana, Y. Uziel, A. Ravelli, G. Schulert, M. Gattorno, J. Frenkel,
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- $a INTRODUCTION: Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting. METHODS: The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha. RESULTS: The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items. CONCLUSION: The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.
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- $a van Delft, Amber Laetitia Justine $u Department of Paediatrics, Universitair Medisch Centrum Utrecht-Locatie Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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