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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
AF. Schmidt, MV. Holmes, D. Preiss, DI. Swerdlow, S. Denaxas, G. Fatemifar, R. Faraway, C. Finan, D. Valentine, Z. Fairhurst-Hunter, FP. Hartwig, BL. Horta, E. Hypponen, C. Power, M. Moldovan, E. van Iperen, K. Hovingh, I. Demuth, K. Norman, E....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
MR/R024227/1
Medical Research Council - United Kingdom
PG/13/66/30442
British Heart Foundation - United Kingdom
064947/Z/01/Z
Wellcome Trust - United Kingdom
U01 AG016976
NIA NIH HHS - United States
FS/18/23/33512
British Heart Foundation - United Kingdom
Department of Health - United Kingdom
U24 AG021886
NIA NIH HHS - United States
AA/18/6/24223
British Heart Foundation - United Kingdom
R01 HL105756
NHLBI NIH HHS - United States
R01 AG033193
NIA NIH HHS - United States
MR/S011676/1
Medical Research Council - United Kingdom
R024227
Medical Research Council - United Kingdom
081081/Z/06/Z
Wellcome Trust - United Kingdom
F32 MH065841
NIMH NIH HHS - United States
K013351
Medical Research Council - United Kingdom
C1298/A8362
Cancer Research UK - United Kingdom
PG/18/50/33837
British Heart Foundation - United Kingdom
FS/14/76/30933
British Heart Foundation - United Kingdom
RG/10/12/28456
British Heart Foundation - United Kingdom
PG/18/5033837
British Heart Foundation - United Kingdom
MC_UU_12015/1
Medical Research Council - United Kingdom
503480
Medical Research Council - United Kingdom
U01 AG032984
NIA NIH HHS - United States
RE/13/1/30181
British Heart Foundation - United Kingdom
Arthritis Research UK - United Kingdom
082604/2/07/Z
Wellcome Trust - United Kingdom
Chief Scientist Office - United Kingdom
SP/13/6/30554
British Heart Foundation - United Kingdom
NLK
BioMedCentral
od 2001-12-01
BioMedCentral Open Access
od 2001
Directory of Open Access Journals
od 2001
Free Medical Journals
od 2001
PubMed Central
od 2001
Europe PubMed Central
od 2001
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2001-01-01
Open Access Digital Library
od 2001-06-01
Open Access Digital Library
od 2001-01-01
Medline Complete (EBSCOhost)
od 2001-01-01
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
Springer Nature OA/Free Journals
od 2001-12-01
- MeSH
- anticholesteremika škodlivé účinky terapeutické užití MeSH
- biologické markery krev MeSH
- celogenomová asociační studie MeSH
- cévní mozková příhoda epidemiologie prevence a kontrola MeSH
- down regulace MeSH
- dyslipidemie krev farmakoterapie epidemiologie genetika MeSH
- hodnocení rizik MeSH
- infarkt myokardu epidemiologie prevence a kontrola MeSH
- inhibitory serinových proteinas škodlivé účinky terapeutické užití MeSH
- ischemie mozku epidemiologie prevence a kontrola MeSH
- jednonukleotidový polymorfismus * MeSH
- LDL-cholesterol krev MeSH
- lidé MeSH
- PCSK9 inhibitory MeSH
- proproteinkonvertasa subtilisin/kexin typu 9 genetika MeSH
- randomizované kontrolované studie jako téma MeSH
- rizikové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
Boston University School of Medicine Boston MA USA
Bradford Institute for Health Research Bradford Royal Infirmary Bradford UK
Center for Human Genetics Marshfield Clinic Research Institute Marshfield USA
Centre for Cardiovascular Genetics Department of Medicine University College London London UK
Centre for Population Health Sciences The Usher Institute University of Edinburgh Edinburgh UK
Children's Hospital of Philadelphia Philadelphia USA
Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands
Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands
Department of Hematology Erasmus MC Cancer Institute 3075 EA Rotterdam the Netherlands
Department of Internal Medicine A University Medicine Greifswald Greifswald Germany
Department of Internal Medicine University Hospital of Cologne Cologne Germany
Department of Medical Sciences Molecular Epidemiology Uppsala University Uppsala Sweden
Department of Medicine Internal Medicine Lausanne University Hospital Lausanne Switzerland
Department of Neurology Medical University Innsbruck Innsbruck Austria
Department of Neurosurgery Bethel Clinic Kantensiek 11 33617 Bielefeld Germany
Department of vascular medicine Academic Medical Center Amsterdam Amsterdam the Netherlands
Department Primary Care and Population Health University College London London UK
Division of Genetics and Epidemiology The Institute of Cancer Research London UK
E CA Economics GmbH Berlin Germany
Hematology and Transfusion Medicine Department of Laboratory Medicine BMC B13 SE 221 84 Lund Sweden
Hunter New England Local Health District Newcastle NSW Australia
Institute for Social and Economic Research University of Essex Essex UK
Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow G12 8TA UK
Institute of Cardiovascular Science University College London 222 Euston Road London NW1 2DA UK
Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK
Institute of Health and Wellbeing University of Glasgow Glasgow G12 8RZ Scotland UK
Kaiser Permanente Washington Health Research Institute Seattle WA USA
l'institut du Thorax INSERM CNRS UNIV Nantes CHU Nantes Nantes France
Lithuanian University of Health Sciences Kaunas Lithuania
National Institute of Public Health Prague Czech Republic
Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK
Population Health Research Institute Hamilton Ontario Canada
Population Health Research Institute St George's University of London London UK
Population Health Sciences University of Bristol Bristol UK
Population Policy and Practice UCL GOS Institute of Child Health London UK
Postgraduate Program in Epidemiology Federal University of Pelotas Pelotas Brazil
Robertson Centre for Biostatistics University of Glasgow Glasgow UK
South Australian Health and Medical Research Institute Adelaide Australia
The Department of Medical Research Bærum Hospital Vestre Viken Hospital Trust Gjettum Norway
University College London Farr Institute of Health Informatics London UK
University of Colorado Denver Denver USA
University of Minnesota Minneapolis USA
University of Newcastle Newcastle NSW Australia
Vanderbilt University Nashville USA
Wellcome Trust Centre for Human Genetics University of Oxford Oxford England
Citace poskytuje Crossref.org
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- $a Schmidt, Amand F $u Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. amand.schmidt@ucl.ac.uk. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. amand.schmidt@ucl.ac.uk. UCL's BHF Research Accelerator Centre, London, UK. amand.schmidt@ucl.ac.uk.
- 245 10
- $a Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 / $c AF. Schmidt, MV. Holmes, D. Preiss, DI. Swerdlow, S. Denaxas, G. Fatemifar, R. Faraway, C. Finan, D. Valentine, Z. Fairhurst-Hunter, FP. Hartwig, BL. Horta, E. Hypponen, C. Power, M. Moldovan, E. van Iperen, K. Hovingh, I. Demuth, K. Norman, E. Steinhagen-Thiessen, J. Demuth, L. Bertram, CM. Lill, S. Coassin, J. Willeit, S. Kiechl, K. Willeit, D. Mason, J. Wright, R. Morris, G. Wanamethee, P. Whincup, Y. Ben-Shlomo, S. McLachlan, JF. Price, M. Kivimaki, C. Welch, A. Sanchez-Galvez, P. Marques-Vidal, A. Nicolaides, AG. Panayiotou, NC. Onland-Moret, YT. van der Schouw, G. Matullo, G. Fiorito, S. Guarrera, C. Sacerdote, NJ. Wareham, C. Langenberg, RA. Scott, J. Luan, M. Bobak, S. Malyutina, A. Pająk, R. Kubinova, A. Tamosiunas, H. Pikhart, N. Grarup, O. Pedersen, T. Hansen, A. Linneberg, T. Jess, J. Cooper, SE. Humphries, M. Brilliant, T. Kitchner, H. Hakonarson, DS. Carrell, CA. McCarty, KH. Lester, EB. Larson, DR. Crosslin, M. de Andrade, DM. Roden, JC. Denny, C. Carty, S. Hancock, J. Attia, E. Holliday, R. Scott, P. Schofield, M. O'Donnell, S. Yusuf, M. Chong, G. Pare, P. van der Harst, MA. Said, RN. Eppinga, N. Verweij, H. Snieder, Lifelines Cohort authors, T. Christen, DO. Mook-Kanamori, ICBP Consortium, S. Gustafsson, L. Lind, E. Ingelsson, R. Pazoki, O. Franco, A. Hofman, A. Uitterlinden, A. Dehghan, A. Teumer, S. Baumeister, M. Dörr, MM. Lerch, U. Völker, H. Völzke, J. Ward, JP. Pell, T. Meade, IE. Christophersen, AH. Maitland-van der Zee, EV. Baranova, R. Young, I. Ford, A. Campbell, S. Padmanabhan, ML. Bots, DE. Grobbee, P. Froguel, D. Thuillier, R. Roussel, A. Bonnefond, B. Cariou, M. Smart, Y. Bao, M. Kumari, A. Mahajan, JC. Hopewell, S. Seshadri, METASTROKE Consortium of the ISGC, C. Dale, RPE. Costa, PM. Ridker, DI. Chasman, AP. Reiner, MD. Ritchie, LA. Lange, AJ. Cornish, SE. Dobbins, K. Hemminki, B. Kinnersley, M. Sanson, K. Labreche, M. Simon, M. Bondy, P. Law, H. Speedy, J. Allan, N. Li, M. Went, N. Weinhold, G. Morgan, P. Sonneveld, B. Nilsson, H. Goldschmidt, A. Sud, A. Engert, M. Hansson, H. Hemingway, FW. Asselbergs, RS. Patel, BJ. Keating, N. Sattar, R. Houlston, JP. Casas, AD. Hingorani,
- 520 9_
- $a BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
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- 700 1_
- $a Holmes, Michael V $u Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 700 1_
- $a Preiss, David $u Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 700 1_
- $a Swerdlow, Daniel I $u Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. Department of Medicine, Imperial College London, London, UK.
- 700 1_
- $a Denaxas, Spiros $u UCL's BHF Research Accelerator Centre, London, UK. Health Data Research UK, University College London, 222 Euston Road, London, NW1 2DA, UK. Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK. The Alan Turing Institute, British Library, 96 Euston Rd, London, NW1 2DB, UK.
- 700 1_
- $a Fatemifar, Ghazaleh $u UCL's BHF Research Accelerator Centre, London, UK. Health Data Research UK, University College London, 222 Euston Road, London, NW1 2DA, UK. Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Hypponen, Elina $u Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia. Population, Policy and Practice, UCL GOS Institute of Child Health, London, UK. South Australian Health and Medical Research Institute, Adelaide, Australia.
- 700 1_
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- 700 1_
- $a Moldovan, Max $u South Australian Health and Medical Research Institute, Adelaide, Australia.
- 700 1_
- $a van Iperen, Erik $u Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands. Department of Clinical Epidemiology, Biostatistics And Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
- 700 1_
- $a Hovingh, Kees $u Department of vascular medicine, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
- 700 1_
- $a Demuth, Ilja $u Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany. Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany.
- 700 1_
- $a Norman, Kristina $u Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany. Geriatrics Research Group, Charité - Universitätsmedizin Berlin, 13347, Berlin, Germany. Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558, Nuthetal, Germany.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Wright, John $u Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
- 700 1_
- $a Morris, Richard $u Department Primary Care & Population Health, University College London, London, UK.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a McLachlan, Stela $u Centre for Population Health Sciences, The Usher Institute, University of Edinburgh, Edinburgh, UK.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Panayiotou, Andrie G $u Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
- 700 1_
- $a Onland-Moret, N Charlotte $u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 700 1_
- $a van der Schouw, Yvonne T $u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 700 1_
- $a Matullo, Giuseppe $u Italian Institute for Genomic Medicine (IIGM), Turin, Italy. Department of Medical Sciences, University of Turin, Turin, Italy.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Pająk, Andrzej $u Department of Epidemiology and Population Studies, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland.
- 700 1_
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- 700 1_
- $a Tamosiunas, Abdonas $u Lithuanian University of Health Sciences, Kaunas, Lithuania.
- 700 1_
- $a Pikhart, Hynek $u Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Carrell, David S $u Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
- 700 1_
- $a McCarty, Catherine A $u University of Minnesota, Minneapolis, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a de Andrade, Mariza $u Mayo Clinic, Rochester, USA.
- 700 1_
- $a Roden, Dan M $u Department of Medicine, Department of Pharmacology, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 700 1_
- $a Denny, Joshua C $u Vanderbilt University, Nashville, USA.
- 700 1_
- $a Carty, Cara $u WHI, Seattle, USA.
- 700 1_
- $a Hancock, Stephen $u University of Newcastle, Newcastle, NSW, Australia.
- 700 1_
- $a Attia, John $u University of Newcastle, Newcastle, NSW, Australia. Public Health Program, Hunter Medical Research Institute, Newcastle, NSW, Australia.
- 700 1_
- $a Holliday, Elizabeth $u University of Newcastle, Newcastle, NSW, Australia. Public Health Program, Hunter Medical Research Institute, Newcastle, NSW, Australia.
- 700 1_
- $a Scott, Rodney $u University of Newcastle, Newcastle, NSW, Australia.
- 700 1_
- $a Schofield, Peter $u Hunter New England Local Health District, Newcastle, NSW, Australia.
- 700 1_
- $a O'Donnell, Martin $u Population Health Research Institute, Hamilton, Ontario, Canada.
- 700 1_
- $a Yusuf, Salim $u Population Health Research Institute, Hamilton, Ontario, Canada.
- 700 1_
- $a Chong, Michael $u Population Health Research Institute, Hamilton, Ontario, Canada.
- 700 1_
- $a Pare, Guillaume $u Population Health Research Institute, Hamilton, Ontario, Canada.
- 700 1_
- $a van der Harst, Pim $u Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands. Department of Clinical Epidemiology, Biostatistics And Bioinformatics, Academic Medical Center Amsterdam, Amsterdam, the Netherlands. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Said, M Abdullah $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Eppinga, Ruben N $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Verweij, Niek $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Snieder, Harold $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
- 700 1_
- $a Christen, Tim $u Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a Mook-Kanamori, D O $u Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a Gustafsson, Stefan $u Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Lind, Lars $u Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Ingelsson, Erik $u Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
- 700 1_
- $a Pazoki, Raha $u Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
- 700 1_
- $a Franco, Oscar $u Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 700 1_
- $a Hofman, Albert $u Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 700 1_
- $a Uitterlinden, Andre $u Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 700 1_
- $a Dehghan, Abbas $u Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 700 1_
- $a Teumer, Alexander $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- 700 1_
- $a Baumeister, Sebastian $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Chair of Epidemiology, Ludwig-Maximilians-Universität München, UNIKA-T Augsburg, Augsburg, Germany.
- 700 1_
- $a Dörr, Marcus $u DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Lerch, Markus M $u Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Völker, Uwe $u DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Völzke, Henry $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- 700 1_
- $a Ward, Joey $u Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, Scotland, UK.
- 700 1_
- $a Pell, Jill P $u Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, Scotland, UK.
- 700 1_
- $a Meade, Tom $u Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
- 700 1_
- $a Christophersen, Ingrid E $u The Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.
- 700 1_
- $a Maitland-van der Zee, Anke H $u Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands. Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
- 700 1_
- $a Baranova, Ekaterina V $u Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Young, Robin $u Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Ford, Ian $u Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Campbell, Archie $u Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Padmanabhan, Sandosh $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
- 700 1_
- $a Bots, Michiel L $u Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
- 700 1_
- $a Grobbee, Diederick E $u Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
- 700 1_
- $a Froguel, Philippe $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France. Department of Genomics of Common Disease, Imperial College London, W12 0NN, London, United Kingdom.
- 700 1_
- $a Thuillier, Dorothée $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France.
- 700 1_
- $a Roussel, Ronan $u INSERM, U-1138, Centre de Recherche des Cordeliers, Paris, France. UFR de Médecine, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Départment de Diabétologie, Endocrinologie et Nutrition, Assistance Publique Hôpitaux de Paris, Hôpital Bicha, Paris, France.
- 700 1_
- $a Bonnefond, Amélie $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France.
- 700 1_
- $a Cariou, Bertrand $u l'institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
- 700 1_
- $a Smart, Melissa $u Institute for Social and Economic Research, University of Essex, Essex, UK.
- 700 1_
- $a Bao, Yanchun $u Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England.
- 700 1_
- $a Kumari, Meena $u Boston University School of Medicine, Boston, MA, USA.
- 700 1_
- $a Mahajan, Anubha $u Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England.
- 700 1_
- $a Hopewell, Jemma C $u Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK.
- 700 1_
- $a Seshadri, Sudha $u Boston University School of Medicine, Boston, MA, USA.
- 700 1_
- $a Dale, Caroline $u University College London, Farr Institute of Health Informatics, London, UK.
- 700 1_
- $a Costa, Rui Providencia E $u University College London, Farr Institute of Health Informatics, London, UK.
- 700 1_
- $a Ridker, Paul M $u Harvard Medical School Center for Cardiovascular Disease Prevention Brigham and Women's Hospital, Boston, USA.
- 700 1_
- $a Chasman, Daniel I $u Harvard Medical School Center for Cardiovascular Disease Prevention Brigham and Women's Hospital, Boston, USA.
- 700 1_
- $a Reiner, Alex P $u UWash, Seattle, USA.
- 700 1_
- $a Ritchie, Marylyn D $u Penn State, State College, USA.
- 700 1_
- $a Lange, Leslie A $u University of Colorado Denver, Denver, USA.
- 700 1_
- $a Cornish, Alex J $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Dobbins, Sara E $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Hemminki, Kari $u Div. Molecular Genetic Epidemiology German Cancer Research Center, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany. Deutsches Krebsforschungszentrum, Heidelberg, Germany.
- 700 1_
- $a Kinnersley, Ben $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Sanson, Marc $u The Institut du Cerveau et de la Moelle épinière - ICM, Paris, France. Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, F-75013, Paris, France.
- 700 1_
- $a Labreche, Karim $u The Institut du Cerveau et de la Moelle épinière - ICM, Paris, France. Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, F-75013, Paris, France.
- 700 1_
- $a Simon, Matthias $u Department of Neurosurgery, Bethel Clinic, Kantensiek 11, 33617, Bielefeld, Germany.
- 700 1_
- $a Bondy, Melissa $u Division of Hematology-Oncology, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, 77030, USA.
- 700 1_
- $a Law, Philip $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Speedy, Helen $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Allan, James $u Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
- 700 1_
- $a Li, Ni $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Went, Molly $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Weinhold, Niels $u Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
- 700 1_
- $a Morgan, Gareth $u Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
- 700 1_
- $a Sonneveld, Pieter $u Department of Hematology, Erasmus MC Cancer Institute, 3075 EA, Rotterdam, the Netherlands.
- 700 1_
- $a Nilsson, Björn $u Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, SE-221 84, Lund, Sweden.
- 700 1_
- $a Goldschmidt, Hartmut $u University Clinic Heidelberg, Internal Medicine V and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
- 700 1_
- $a Sud, Amit $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Engert, Andreas $u Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Hansson, Markus $u Hematology Clinic, Skåne University Hospital, Skåne, Sweden. Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
- 700 1_
- $a Hemingway, Harry $u UCL's BHF Research Accelerator Centre, London, UK. Health Data Research UK, University College London, 222 Euston Road, London, NW1 2DA, UK. Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK. The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, 222 Euston Road, London, NW1 2DA, UK.
- 700 1_
- $a Asselbergs, Folkert W $u Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. UCL's BHF Research Accelerator Centre, London, UK. Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom.
- 700 1_
- $a Patel, Riyaz S $u Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. UCL's BHF Research Accelerator Centre, London, UK. The Barts Heart Centre, St Bartholomew's Hospital, London, UK.
- 700 1_
- $a Keating, Brendan J $u UPenn, Philadelphia, USA.
- 700 1_
- $a Sattar, Naveed $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
- 700 1_
- $a Houlston, Richard $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Casas, Juan P $u Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) Veterans Affairs Boston Healthcare System, Boston, USA.
- 700 1_
- $a Hingorani, Aroon D $u Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. UCL's BHF Research Accelerator Centre, London, UK.
- 710 2_
- $a Lifelines Cohort authors
- 710 2_
- $a ICBP Consortium
- 710 2_
- $a METASTROKE Consortium of the ISGC
- 773 0_
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