PURPOSE OF REVIEW: Familial hypercholesterolemia (FH) is often perceived and described as underdiagnosed and undertreated, though effective treatment of FH is available. Owing to the mentioned facts, it is ever more imperative to screen and treat FH patients. Subsequent to the identification of patients, the project focuses on the improvement of their prognoses. The ScreenPro FH project was established as a functional international network for the diagnosis, screening, and treatment of FH. Individual countries were assigned goals, e.g., to define the actual situation and available treatment. With "central support," more centers and countries participated in the project. Subsequently, individual countries reported the results at the beginning and end of the project. Collected data were statistically evaluated. RECENT FINDINGS: The increasing number of patients in databases, from 7500 in 2014 to 25,347 in 2018, demonstrates the improvement in overall effectiveness, as well as an increase in the number of centers from 70 to 252. Before all, LDL-C decreased by 41.5% and total cholesterol by 32.3%. As data from all countries and patients were not available at the time of the analysis, only those results from 10 countries and 5585 patients at the beginning of the project and at the time of writing are included. Our data are quite positive. However, our results have only limited validity. Our patients are far from the target levels of LDL-C. The situation can be improved with the introduction of new therapy, PCSK9-i, evolocumab, and alirocumab. International cooperation improved the screening of FH and finally led to an improvement in cardiovascular risk.

3rd Department of Medicine Department of Endocrinology and Metabolism of the 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

Cantonal Hospital Zenica Zenica Bosnia and Herzegovina

Centre for Cardiovascular Surgery and Transplantation Brno Czech Republic Medical Faculty Masaryk University Brno Czech Republic

Clinic for Endocrinology Diabetes and Metabolic Diseases Belgrade Serbia Faculty of Medicine University of Belgrade Belgrade Serbia

Coordination Center for Familial Hyperlipidemias Slovak Medical University Bratislava Slovakia

Department of Internal Medicine Faculty of Medicine University of Debrecen Debrecen Hungary

Head of Department of Ischemic Heart Disease and Atherosclerosis Republican Specialised Center of Cardiology Tashkent Uzbekistan

Institute of Nutrition Faculty of Nursing and Health Professional Studies and Coordination Centre for Familial Hyperlipoproteinemias Slovak Medical University in Bratislava Bratislava Slovakia Institute of Epidemiology School of Medicine Comenius University Bratislava Slovakia

Latvian Research Institute of Cardiology Faculty of Medicine University of Latvia Riga Latvia Paul Stradins Clinical University Hospital Riga Latvia

National Cardiology Research Center Moscow Russia

National Registry Coordinator in Ukraine Kiev Ukraine

Vilnius University Faculty of Medicine Vilnius Lithuania Vilnius University Hospital Santaros Klinikos Vilnius Lithuania

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