-
Je něco špatně v tomto záznamu ?
The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients
Z. Strizova, M. Snajdauf, D. Stakheev, P. Taborska, J. Vachtenheim, J. Biskup, R. Lischke, J. Bartunkova, D. Smrz,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
Grantová podpora
GA UK No. 364218
Univerzita Karlova v Praze
PRIMUS/MED/12
Univerzita Karlova v Praze
AZV 16-28135A
Ministerstvo Zdravotnictví Ceské Republiky
- MeSH
- adenokarcinom imunologie patologie terapie MeSH
- antigeny CD95 imunologie MeSH
- buňky NK imunologie patologie MeSH
- CD4-pozitivní T-lymfocyty imunologie patologie MeSH
- CD8-pozitivní T-lymfocyty imunologie patologie MeSH
- imunoterapie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfatické uzliny imunologie patologie MeSH
- lymfocyty imunologie patologie MeSH
- nádory jícnu imunologie patologie terapie MeSH
- senioři MeSH
- skvamózní karcinom jícnu imunologie patologie terapie MeSH
- studie případů a kontrol MeSH
- T-lymfocyty - podskupiny imunologie patologie MeSH
- tumor infiltrující lymfocyty imunologie patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
PURPOSE: Esophageal cancer (EC) is one of the most lethal gastrointestinal malignancies. Immunotherapy is a promising treatment modality for this disease. However, broader implementation of EC immunotherapy has been discouraged because of insufficient understanding of tumor interactions with the immune system. As with other malignancies, the current research on EC focuses on deciphering the immune cell signatures within the tumor microenvironment. However, the disease-elicited immune cell profiles in the paratumoral compartments are largely unknown. METHODS: We examined the immune cell signatures in 62 tissue samples from 16 EC patients in different esophageal tissue compartments: tumor tissue, peritumoral tissue, healthy esophageal tissue, and adjacent lymph nodes. We analyzed the proportions and distribution patterns of NK cells and CD4+ and CD8+ T cells as well as their death receptor (FasR, FasR/DR3)-expressing subpopulations. The analyzed data were then compared and correlated with the patients' clinicopathological data. RESULTS: We found that the FasR+ NK cells, CD4+ and CD8+ T cells infiltrated lymph nodes at the lowest levels and that the FasR+DR3+ CD4+ T cells were enhanced in tumors. The comparisons with the clinicopathological data revealed a major impact of active smoking on the reduction in paratumoral NK cells and the upregulation of FasR in tumor-infiltrating NK and CD8+ T cells. The lymph node metastatic stage, tumor stage, and Mandard grade correlated with the compartmental proportions of the evaluated immune cells. CONCLUSION: The novel association of the disease state with tumoral and paratumoral immune cell signatures suggests new possibilities for personalized immunotherapy for EC patients.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20024845
- 003
- CZ-PrNML
- 005
- 20201222160014.0
- 007
- ta
- 008
- 201125s2020 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00432-020-03258-y $2 doi
- 035 __
- $a (PubMed)32447483
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Strizova, Zuzana $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic.
- 245 14
- $a The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients / $c Z. Strizova, M. Snajdauf, D. Stakheev, P. Taborska, J. Vachtenheim, J. Biskup, R. Lischke, J. Bartunkova, D. Smrz,
- 520 9_
- $a PURPOSE: Esophageal cancer (EC) is one of the most lethal gastrointestinal malignancies. Immunotherapy is a promising treatment modality for this disease. However, broader implementation of EC immunotherapy has been discouraged because of insufficient understanding of tumor interactions with the immune system. As with other malignancies, the current research on EC focuses on deciphering the immune cell signatures within the tumor microenvironment. However, the disease-elicited immune cell profiles in the paratumoral compartments are largely unknown. METHODS: We examined the immune cell signatures in 62 tissue samples from 16 EC patients in different esophageal tissue compartments: tumor tissue, peritumoral tissue, healthy esophageal tissue, and adjacent lymph nodes. We analyzed the proportions and distribution patterns of NK cells and CD4+ and CD8+ T cells as well as their death receptor (FasR, FasR/DR3)-expressing subpopulations. The analyzed data were then compared and correlated with the patients' clinicopathological data. RESULTS: We found that the FasR+ NK cells, CD4+ and CD8+ T cells infiltrated lymph nodes at the lowest levels and that the FasR+DR3+ CD4+ T cells were enhanced in tumors. The comparisons with the clinicopathological data revealed a major impact of active smoking on the reduction in paratumoral NK cells and the upregulation of FasR in tumor-infiltrating NK and CD8+ T cells. The lymph node metastatic stage, tumor stage, and Mandard grade correlated with the compartmental proportions of the evaluated immune cells. CONCLUSION: The novel association of the disease state with tumoral and paratumoral immune cell signatures suggests new possibilities for personalized immunotherapy for EC patients.
- 650 _2
- $a adenokarcinom $x imunologie $x patologie $x terapie $7 D000230
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a CD4-pozitivní T-lymfocyty $x imunologie $x patologie $7 D015496
- 650 _2
- $a CD8-pozitivní T-lymfocyty $x imunologie $x patologie $7 D018414
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a nádory jícnu $x imunologie $x patologie $x terapie $7 D004938
- 650 _2
- $a skvamózní karcinom jícnu $x imunologie $x patologie $x terapie $7 D000077277
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunoterapie $x metody $7 D007167
- 650 _2
- $a buňky NK $x imunologie $x patologie $7 D007694
- 650 _2
- $a lymfatické uzliny $x imunologie $x patologie $7 D008198
- 650 _2
- $a lymfocyty $x imunologie $x patologie $7 D008214
- 650 _2
- $a tumor infiltrující lymfocyty $x imunologie $x patologie $7 D016246
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a T-lymfocyty - podskupiny $x imunologie $x patologie $7 D016176
- 650 _2
- $a antigeny CD95 $x imunologie $7 D019014
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Snajdauf, Martin $u Third Department of Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
- 700 1_
- $a Stakheev, Dmitry $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic.
- 700 1_
- $a Taborska, Pavla $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic.
- 700 1_
- $a Vachtenheim, Jiri $u Third Department of Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
- 700 1_
- $a Biskup, Jan $u Department of Radiology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
- 700 1_
- $a Lischke, Robert $u Third Department of Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
- 700 1_
- $a Bartunkova, Jirina $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic.
- 700 1_
- $a Smrz, Daniel $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, Praha 5, 150 06, Prague, Czech Republic. daniel.smrz@lfmotol.cuni.cz.
- 773 0_
- $w MED00005752 $t Journal of cancer research and clinical oncology $x 1432-1335 $g Roč. 146, č. 8 (2020), s. 1979-1992
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32447483 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201222160010 $b ABA008
- 999 __
- $a ok $b bmc $g 1598990 $s 1115531
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 146 $c 8 $d 1979-1992 $e 20200523 $i 1432-1335 $m JBIC, Journal of biological inorganic chemistry $n J Biol Inorg Chem $x MED00005752
- GRA __
- $a GA UK No. 364218 $p Univerzita Karlova v Praze
- GRA __
- $a PRIMUS/MED/12 $p Univerzita Karlova v Praze
- GRA __
- $a AZV 16-28135A $p Ministerstvo Zdravotnictví Ceské Republiky
- LZP __
- $a Pubmed-20201125
