-
Something wrong with this record ?
Papel de la PET/TC con 18F-DOPA en el diagnóstico de la forma congénita focal del hiperinsulinismo en niños
[The role of 18F-DOPA PET/CT in the diagnosis of the congenital focal form of hyperinsulinism in children]
D. Chroustova, J. Trnka, A. Pudlac, B. Obermannova, L. Lambert
Language xxx, English Country Spain
Document type Journal Article
- MeSH
- Surgery, Computer-Assisted * MeSH
- Diazoxide therapeutic use MeSH
- Dihydroxyphenylalanine analogs & derivatives pharmacokinetics MeSH
- Insulinoma complications surgery MeSH
- Infant MeSH
- Combined Modality Therapy MeSH
- Humans MeSH
- Pancreatic Neoplasms complications surgery MeSH
- Neuroendocrine Cells metabolism MeSH
- Octreotide therapeutic use MeSH
- Pancreas physiopathology MeSH
- Pancreatectomy methods MeSH
- Positron Emission Tomography Computed Tomography methods MeSH
- Positron-Emission Tomography MeSH
- Child, Preschool MeSH
- Radiopharmaceuticals * pharmacokinetics MeSH
- Fluorine Radioisotopes * pharmacokinetics MeSH
- Sulfonylurea Receptors genetics MeSH
- Retrospective Studies MeSH
- Sirolimus therapeutic use MeSH
- Tissue Distribution MeSH
- Congenital Hyperinsulinism diagnostic imaging drug therapy physiopathology surgery MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Congenital hyperinsulinism (CHI) is a neuroendocrine disease with focal or diffuse abnormalities in pancreas. While drug-resistant diffuse forms require near-total pancreatectomy or prolonged pharmacotherapy, focal CHI may be treated by targeted surgical resection. We evaluated the usefulness of 18F-DOPA PET/CT to identify the focal pancreatic form. SUBJECTS AND METHODS: Nineteen children (11 boys, 8 girls, aged 2-54 months) with clinical signs of neonatal CHI and positive genetic examinations were enrolled in the study. After i.v. administration of 18F-DOPA, early PET and late PET/CT acquisition covering one-bed length over thoraco-abdominal region were performed. Both acquisitions were done in dynamic mode to allow exclusion of frames with motion artefacts. Standardized uptake values were adjusted to bodyweight (SUVbw). The finding was considered as focal when the ratio of SUVbwmax between the suspicious region and the rest of pancreas was greater than 1.2. RESULTS: Focal forms were recorded in 10/19 children and 4 of them underwent surgical resection with complete recovery. Focal uptake was significantly higher than the uptake in the normal pancreatic tissue (p=0.0059). Focal and diffuse forms of CHI did not differ significantly in normal pancreatic tissue uptake. We found no advantage in the measurement of SUVbwmean ratio compared to SUVbwmax ratio (p=0.50). CONCLUSION: 18F-DOPA PET/CT is a useful tool for the localization of focal CHI and planning of surgical treatment.
The role of 18F-DOPA PET/CT in the diagnosis of the congenital focal form of hyperinsulinism in children
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21020841
- 003
- CZ-PrNML
- 005
- 20210830102456.0
- 007
- ta
- 008
- 210728s2020 sp f 000 0|eng s
- 009
- AR
- 024 7_
- $a 10.1016/j.remn.2020.02.005 $2 doi
- 035 __
- $a (PubMed)32448747
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng spa
- 044 __
- $a sp
- 100 1_
- $a Chroustova, D $u Department of Nuclear Medicine, General University Hospital and First Faculty of Medicine, Charles University, Praga, República Checa. Electronic address: daniela.chroustova@vfn.cz
- 245 10
- $a Papel de la PET/TC con 18F-DOPA en el diagnóstico de la forma congénita focal del hiperinsulinismo en niños / $c D. Chroustova, J. Trnka, A. Pudlac, B. Obermannova, L. Lambert
- 246 31
- $a The role of 18F-DOPA PET/CT in the diagnosis of the congenital focal form of hyperinsulinism in children
- 520 9_
- $a BACKGROUND: Congenital hyperinsulinism (CHI) is a neuroendocrine disease with focal or diffuse abnormalities in pancreas. While drug-resistant diffuse forms require near-total pancreatectomy or prolonged pharmacotherapy, focal CHI may be treated by targeted surgical resection. We evaluated the usefulness of 18F-DOPA PET/CT to identify the focal pancreatic form. SUBJECTS AND METHODS: Nineteen children (11 boys, 8 girls, aged 2-54 months) with clinical signs of neonatal CHI and positive genetic examinations were enrolled in the study. After i.v. administration of 18F-DOPA, early PET and late PET/CT acquisition covering one-bed length over thoraco-abdominal region were performed. Both acquisitions were done in dynamic mode to allow exclusion of frames with motion artefacts. Standardized uptake values were adjusted to bodyweight (SUVbw). The finding was considered as focal when the ratio of SUVbwmax between the suspicious region and the rest of pancreas was greater than 1.2. RESULTS: Focal forms were recorded in 10/19 children and 4 of them underwent surgical resection with complete recovery. Focal uptake was significantly higher than the uptake in the normal pancreatic tissue (p=0.0059). Focal and diffuse forms of CHI did not differ significantly in normal pancreatic tissue uptake. We found no advantage in the measurement of SUVbwmean ratio compared to SUVbwmax ratio (p=0.50). CONCLUSION: 18F-DOPA PET/CT is a useful tool for the localization of focal CHI and planning of surgical treatment.
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a kombinovaná terapie $7 D003131
- 650 _2
- $a vrozený hyperinzulinismus $x diagnostické zobrazování $x farmakoterapie $x patofyziologie $x chirurgie $7 D044903
- 650 _2
- $a diazoxid $x terapeutické užití $7 D003981
- 650 _2
- $a dihydroxyfenylalanin $x analogy a deriváty $x farmakokinetika $7 D004295
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a radioizotopy fluoru $x farmakokinetika $7 D005462
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a inzulinom $x komplikace $x chirurgie $7 D007340
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a neuroendokrinní buňky $x metabolismus $7 D055099
- 650 _2
- $a oktreotid $x terapeutické užití $7 D015282
- 650 _2
- $a pankreas $x patofyziologie $7 D010179
- 650 _2
- $a pankreatektomie $x metody $7 D010180
- 650 _2
- $a nádory slinivky břišní $x komplikace $x chirurgie $7 D010190
- 650 _2
- $a PET/CT $x metody $7 D000072078
- 650 _2
- $a pozitronová emisní tomografie $7 D049268
- 650 12
- $a radiofarmaka $x farmakokinetika $7 D019275
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a sirolimus $x terapeutické užití $7 D020123
- 650 _2
- $a receptory sulfonylurey $x genetika $7 D064233
- 650 12
- $a chirurgie s pomocí počítače $7 D025321
- 650 _2
- $a tkáňová distribuce $7 D014018
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Trnka, J $u Department of Nuclear Medicine, General University Hospital and First Faculty of Medicine, Charles University, Praga, República Checa; Department of Medical Physics, General University Hospital, Praga, República Checa
- 700 1_
- $a Pudlac, A $u Department of Radiology, General University Hospital and First Faculty Medicine, Charles University, Praga, República Checa
- 700 1_
- $a Obermannova, B $u Department of Paediatrics, Second Faculty of Medicine, Charles University in Prague and University Hospital Motol, Praga, República Checa
- 700 1_
- $a Lambert, L $u Department of Radiology, General University Hospital and First Faculty Medicine, Charles University, Praga, República Checa
- 773 0_
- $w MED00207805 $t Revista española de medicina nuclear e imagen molecular $x 2253-8089 $g Roč. 39, č. 5 (2020), s. 279-283
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32448747 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210728 $b ABA008
- 991 __
- $a 20210830102456 $b ABA008
- 999 __
- $a ok $b bmc $g 1691431 $s 1141287
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 39 $c 5 $d 279-283 $e 20200521 $i 2253-8089 $m Revista española de medicina nuclear e imagen molecular (Internet. English ed.) $n Rev Esp Med Nucl Imagen Mol (Engl Ed) $x MED00207805
- LZP __
- $a Pubmed-20210728
