Growth and production of anthracyclines in wild-type and mutant strains of Streptomyces galilaeus
Language English Country United States Media print
Document type Journal Article
PubMed
527904
DOI
10.1007/bf02926647
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents biosynthesis MeSH
- DNA, Bacterial biosynthesis MeSH
- Species Specificity MeSH
- Fermentation MeSH
- Glucose metabolism MeSH
- Glycosides biosynthesis MeSH
- Mutation MeSH
- Naphthacenes biosynthesis MeSH
- Streptomyces genetics growth & development metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- DNA, Bacterial MeSH
- Glucose MeSH
- Glycosides MeSH
- Naphthacenes MeSH
The course of growth curves with respect to the biosynthesis of anthracyclines was followed in the wild low-producing strain Streptomyces galilaeus JA 3043 and in its mutants G-167 (producing increased quantities of glycosides of epsilon-pyrromycinone) and J-14 (accumulating free epsilon-pyrromycinone). A two-phase type of fermentation (growth phase, production phase) was observed in strains JA 3043 and J-14. The maximum production of anthracyclines occurred only after the end of intense growth of the culture. Two phases of rapid growth separated by a phase of stagnation were observed in strain G-167. The second growth phase proceeded only during late hours of cultivation and was (as compared with the first phase) associated with an intensive biosynthesis of anthracyclines.
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