5,5-Diethylbarbituric acid (barbital) stimulates the production of anthracycline antibiotics called galirubins in Streptomyces galilaeus in dependence on the strain, concentration and cultivation conditions. The stimulation is more pronounced (up to 300%) in the low-producing strain than in the production mutant. Under conditions of limited aeration the effect of barbital is increased in both strains. In the production strain barbital narrows the spectrum of metabolites produced. Higher barbital concentrations inhibit growth of the mycelium of both strains and decrease the formation of free anthracyclinones.

See more in PubMed

J Biol Chem. 1974 Oct 25;249(20):6439-45 PubMed

J Cell Biol. 1965 Sep 1;26(3):725-33 PubMed

Chem Ber. 1967;100(8):2561-8 PubMed

Arch Biochem Biophys. 1962 Mar;96:583-7 PubMed

Z Allg Mikrobiol. 1977;17(1):47-50 PubMed

Appl Microbiol. 1957 Sep;5(5):339-43 PubMed

Appl Microbiol. 1961 Jul;9:325-34 PubMed

Z Allg Mikrobiol. 1966;6(5):361-5 PubMed

Acta Microbiol Pol B. 1972;4(4):201-9 PubMed

Ann N Y Acad Sci. 1954 Oct 29;60(1):136-51 PubMed

Appl Microbiol. 1965 Jul;13:600-4 PubMed

Growth and production of anthracyclines in wild-type and mutant strains of Streptomyces galilaeus

Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins

Studies on the production of daunomycinone-derived glycosides and related metabolites in Streptomyces coeruleorubidus and Streptomyces peucetius