Variation of antimetabolite sensitivity with different carbon sources in Bacillus subtilis
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
6806159
DOI
10.1007/bf02879762
Knihovny.cz E-resources
- MeSH
- Arabinose metabolism MeSH
- Bacillus subtilis drug effects metabolism MeSH
- Cysteine analogs & derivatives pharmacology MeSH
- Ethionine pharmacology MeSH
- Glucose metabolism MeSH
- Glycerol metabolism MeSH
- Hydroxylysine pharmacology MeSH
- Maltose metabolism MeSH
- Mannitol metabolism MeSH
- Carbohydrate Metabolism * MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Arabinose MeSH
- Cysteine MeSH
- Ethionine MeSH
- Glucose MeSH
- Glycerol MeSH
- Hydroxylysine MeSH
- Maltose MeSH
- Mannitol MeSH
- S-2-aminoethyl cysteine MeSH Browser
The susceptibility of Bacillus subtilis to amino acid analogues was found to be markedly influenced by the carbon source used in the test media. Thialysine inhibited the bacterium with a greater number of carbon sources than the other two analogues tested. 5-Hydroxylysine was inhibitory with glycerol, lactose, D-xylose, L-arabinose and soluble starch while ethionine showed toxicity with lactose, D-xylose and L-arabinose. None of these analogues were toxic at the levels tested when D-galactose was used as carbon source. The bacterium was not susceptible to thialysine with glycerol, to 5-hydroxylysine with L-arabinose and to ethionine with lactose.
