Vascular histopathologic reaction to pulmonary artery banding in an in vivo growing porcine model
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- arteria pulmonalis patologie chirurgie MeSH
- hemodynamika MeSH
- ligace MeSH
- modely nemocí na zvířatech MeSH
- následné studie MeSH
- prasata MeSH
- svaly hladké cévní patologie MeSH
- vrozené srdeční vady patologie chirurgie MeSH
- výkony cévní chirurgie metody MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Pulmonary artery banding (PAB) is used as a surgical palliation to reduce excessive pulmonary blood flow caused by congenital heart defects. Due to the lack of microscopic studies dealing with the tissue remodeling caused by contemporary PAB materials, this study aimed to assess histologic changes associated with PAB surgery by analyzing local tissue reaction to the presence of Gore-Tex strips fixed around the pulmonary artery. Gore-Tex strips were used for PAB in a growing porcine model. After 5 weeks, histologic samples with PAB (n = 5) were compared with healthy pulmonary arterial segments distal to the PAB or from a sham-treated animal (n = 1). Stereology was used to quantify the density of the vasa vasorum and the area fraction of elastin, smooth muscle actin, macrophages, and nervi vasorum within the pulmonary arterial wall. The null hypothesis stated that samples did not differ histopathologically from adjacent vascular segments or sham-treated samples. The PAB samples had a greater area fraction of macrophages, a lower amount of nervi vasorum, and a tendency toward decreased smooth muscle content compared with samples that had no PAB strips. There was no destruction of elastic membranes, no medionecrosis, no pronounced inflammatory infiltration or foreign body reaction, and no vasa vasorum deficiency after the PAB. All the histopathologic changes were limited to the banded vascular segment and did not affect distal parts of the pulmonary artery. The study results show the tissue reaction of palliative PAB and suggest that Gore-Tex strips used contemporarily for PAB do not cause severe local histologic damage to the banded segment of the pulmonary arterial wall after 5 weeks in a porcine PAB model.
Zobrazit více v PubMed
Ann Thorac Surg. 1990 Jul;50(1):94-7 PubMed
Folia Morphol (Praha). 1970;18(3):293-5 PubMed
Physiol Rev. 2004 Jul;84(3):767-801 PubMed
Cesk Pediatr. 1973;28(5):220-2 PubMed
Cardiovasc Intervent Radiol. 1988 Jun;11(3):150-4 PubMed
Surgery. 1969 May;65(5):808-18 PubMed
Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H295-305 PubMed
Cell Tissue Res. 2007 Apr;328(1):185-95 PubMed
Ann Thorac Surg. 2010 Jan;89(1):174-9 PubMed
Eur J Cardiothorac Surg. 2006 May;29(5):666-73; discussion 673-4 PubMed
J Thorac Cardiovasc Surg. 1979 Jul;78(1):28-31 PubMed
J Thorac Cardiovasc Surg. 2003 Feb;125(2):231-7 PubMed
J Thorac Cardiovasc Surg. 2012 Sep;144(3):553-6 PubMed
Tohoku J Exp Med. 2011;225(4):255-62 PubMed
Cell Tissue Res. 2002 Mar;307(3):303-13 PubMed
Eur Heart J. 2012 Jan;33(1):61-6 PubMed
Histochem Cell Biol. 2010 Feb;133(2):241-59 PubMed
Am J Cardiol. 1968 Feb;21(2):174-84 PubMed
Ann Surg. 1974 May;179(5):805-12 PubMed
Ann Thorac Surg. 2010 Mar;89(3):973-5 PubMed
Surg Gynecol Obstet. 1952 Aug;95(2):213-9 PubMed
Pathobiology. 2013;80(1):11-23 PubMed
Pediatr Cardiol. 2010 Jan;31(1):136-7 PubMed
Pediatr Cardiol. 2013;34(8):2024-6 PubMed
Gen Thorac Cardiovasc Surg. 2008 Feb;56(2):54-61 PubMed
Pediatr Cardiol. 2013;34(8):1935-7 PubMed
J Surg Res. 2011 Nov;171(1):170-4 PubMed
