Occurrence of extended-spectrum beta-lactamases among Escherichia coli isolates from hospitalized and healthy children
Language English Country United States Media print
Document type Journal Article
PubMed
12800510
DOI
10.1007/bf02930963
Knihovny.cz E-resources
- MeSH
- beta-Lactamases metabolism MeSH
- beta-Lactam Resistance MeSH
- beta-Lactams pharmacology MeSH
- Child MeSH
- Escherichia coli classification enzymology isolation & purification MeSH
- Hospitalization * MeSH
- Escherichia coli Infections epidemiology microbiology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Child, Preschool MeSH
- Diarrhea epidemiology microbiology MeSH
- Intestinal Mucosa microbiology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Child, Preschool MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- beta-Lactamases MeSH
- beta-Lactams MeSH
The prevalence of extended-spectrum beta-lactamases (ESBL) was determined among isolates of Escherichia coli (n = 63) isolated from hospitalized (43) and healthy (20) children. Ten isolates (21%) were ESBL-positive for two screening tests, the double disk-synergy test and the Oxoid Combination Disk method. One ESBL-positive isolate came from a healthy child. The transfer frequency of oxyimino-beta-lactam resistance from ESBL-producing isolates to E. coli K12 C600 recipient strain ranged from 10(-8) to 10(-5) per donor cell. Donor strains and transconjugants displayed susceptibility patterns typical of ESBL producers. They were resistant to oxyimino-beta-lactams but susceptible to clavulanic acid and carbapenems. Seven out of the 10 ESBL-positive isolates were found to produce MR/MS fimbria, which may play an important role in the colonization of the human intestinal mucosa.
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