Yeast as a model organism to study transport and homeostasis of alkali metal cations
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15119939
Knihovny.cz E-resources
- MeSH
- Cell Membrane metabolism MeSH
- Homeostasis MeSH
- Ion Transport MeSH
- Cations, Monovalent MeSH
- Metals metabolism MeSH
- Sodium-Hydrogen Exchangers genetics metabolism MeSH
- Saccharomyces cerevisiae genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Cations, Monovalent MeSH
- Metals MeSH
- Sodium-Hydrogen Exchangers MeSH
To maintain an optimum cytoplasmic K(+)/Na+ ratio, cells employ three distinct strategies: 1) strict discrimination among alkali metal cations at the level of influx, 2) efficient efflux of toxic cations from cells, and 3) selective sequestration of cations in organelles. Cation efflux and influx are mediated in cells by systems with different substrate specificities and diverse mechanisms, e.g. ATPases, symporters, antiporters, and channels. Simple eukaryotic yeast Saccharomyces cerevisiae cells proved to be an excellent model for studying the transport properties and physiological function of alkali-metal-cation transporters, and the existence of mutant strains lacking their own transport systems provided an efficient tool for a molecular study of alkali-metal-cation transporters from higher eukaryotes upon their expression in yeast cells.
Four pathogenic Candida species differ in salt tolerance
Functional comparison of plasma-membrane Na+/H+ antiporters from two pathogenic Candida species
Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison