Yeast as a model organism to study transport and homeostasis of alkali metal cations
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
15119939
Knihovny.cz E-zdroje
- MeSH
- buněčná membrána metabolismus MeSH
- homeostáza MeSH
- iontový transport MeSH
- kationty jednomocné MeSH
- kovy metabolismus MeSH
- Na(+)-H(+) antiport genetika metabolismus MeSH
- Saccharomyces cerevisiae genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- kationty jednomocné MeSH
- kovy MeSH
- Na(+)-H(+) antiport MeSH
To maintain an optimum cytoplasmic K(+)/Na+ ratio, cells employ three distinct strategies: 1) strict discrimination among alkali metal cations at the level of influx, 2) efficient efflux of toxic cations from cells, and 3) selective sequestration of cations in organelles. Cation efflux and influx are mediated in cells by systems with different substrate specificities and diverse mechanisms, e.g. ATPases, symporters, antiporters, and channels. Simple eukaryotic yeast Saccharomyces cerevisiae cells proved to be an excellent model for studying the transport properties and physiological function of alkali-metal-cation transporters, and the existence of mutant strains lacking their own transport systems provided an efficient tool for a molecular study of alkali-metal-cation transporters from higher eukaryotes upon their expression in yeast cells.
Four pathogenic Candida species differ in salt tolerance
Functional comparison of plasma-membrane Na+/H+ antiporters from two pathogenic Candida species
Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison
