Hephaestin--a ferroxidase of cellular iron export
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15778082
DOI
10.1016/j.biocel.2004.12.007
PII: S1357-2725(04)00432-7
Knihovny.cz E-resources
- MeSH
- Ceruloplasmin metabolism MeSH
- Colon metabolism MeSH
- Humans MeSH
- Membrane Proteins biosynthesis physiology MeSH
- Mice, Mutant Strains MeSH
- Mice MeSH
- Intestine, Small metabolism MeSH
- Iron metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ceruloplasmin MeSH
- HEPH protein, human MeSH Browser
- Heph protein, mouse MeSH Browser
- Membrane Proteins MeSH
- Iron MeSH
Hephaestin is a transmembrane copper-dependent ferroxidase necessary for effective iron transport from intestinal enterocytes into the circulation. Hephaestin is mutated in sex-linked anemia (sla) mice. The initial uptake of iron from the diet in these animals is normal, but the basolateral export of iron from enterocytes is defective, resulting in iron deficiency and microcytic hypochromic anemia. In addition to the small intestine, hephaestin is expressed to a lesser extent in colon, spleen, placenta and kidney but its role in these tissues remains unknown. So far, hephaestin has not been linked to a human disease.
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