Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16453390
DOI
10.1002/bip.20461
Knihovny.cz E-resources
- MeSH
- Biodegradation, Environmental MeSH
- Biocompatible Materials chemical synthesis MeSH
- Cyanogen Bromide chemistry MeSH
- Chromatography, Gel MeSH
- Glycosaminoglycans chemistry MeSH
- Hyaluronoglucosaminidase pharmacology MeSH
- Hydroxyl Radical chemistry MeSH
- Carbamates chemical synthesis MeSH
- Kinetics MeSH
- Hyaluronic Acid chemical synthesis chemistry MeSH
- Nuclear Magnetic Resonance, Biomolecular MeSH
- Solubility MeSH
- Cattle MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Viscosity MeSH
- Water chemistry MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Cyanogen Bromide MeSH
- Glycosaminoglycans MeSH
- Hyaluronoglucosaminidase MeSH
- Hydroxyl Radical MeSH
- Carbamates MeSH
- Hyaluronic Acid MeSH
- Water MeSH
Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans preserves the carboxyl groups and retains properties of polyelectrolyte. This method affords derivatives easily and the reaction condition correlates with degree of substitution. The experimental results show the effect of reaction conditions (reaction time, ratio of reactants) and effect of substitution on biodegradability. The obtained materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy.
References provided by Crossref.org
