New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16821707
DOI
10.1007/bf02931445
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Antitubercular Agents pharmacology MeSH
- Indoles chemistry pharmacology MeSH
- Isoniazid pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium avium Complex drug effects MeSH
- Mycobacterium fortuitum drug effects MeSH
- Mycobacterium kansasii drug effects MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Nontuberculous Mycobacteria drug effects MeSH
- Thiones chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 2,3-dihydro-1-butyl-2-thioxoindole-3-one MeSH Browser
- 2,3-dihydro-1-methyl-2-thioxoindole-3-one MeSH Browser
- Anti-Bacterial Agents MeSH
- Antitubercular Agents MeSH
- Indoles MeSH
- Isoniazid MeSH
- Thiones MeSH
A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide.
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