In vivo effects of dental casting alloys
Language English Country Sweden Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16892010
PII: NEL270706A07
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation MeSH
- Hypersensitivity etiology MeSH
- Chronic Disease MeSH
- Adult MeSH
- Gingiva drug effects pathology MeSH
- Corrosion MeSH
- Metals adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Electron Probe Microanalysis MeSH
- Pigmentation Disorders etiology MeSH
- Aged MeSH
- Mouth Mucosa drug effects pathology MeSH
- Dental Alloys adverse effects MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Metals MeSH
- Dental Alloys MeSH
OBJECTIVE: Corrosion products of different metallic alloys used in prosthetic dentistry often cause the development of a bluish-grey pigmentation of gingiva and oral mucosa. The aim of this study was to determine the content of metals in metallic pigmentations and evaluate the immune response to metals found in the oral cavity. MATERIAL AND METHODS: The local tissue reactions were investigated clinically by electron microscopy and by energy dispersive x-ray microanalysis. An extensive anamnesis of the patients was recorded as well as earlier contacts with health care institutions. The immunological response to metallic components of dental alloys was evaluated in 34 patients by MELISA, a modified test for lymphocyte proliferation. In addition, cytokines in culture media were determined in 10 persons by the Human Inflammation Antibody Array. RESULTS: Dense particles containing metals were found in the matrix among collagen fibrils and in close proximity of the lamina basalis of the gingival epithelium. Particles were also localized intracellularly in fibroblasts, macrophages, and endothelial cells. Metallic depositions consisted predominantly of silver accompanied by selenium and sulphur. Twenty five out of 34 patients revealed high lymphocyte reactivity (positive MELISA test) to one or more metal components of dental restorations. A correlation between the positivity in MELISA test and number of dental alloys in the oral cavity was also found. Twenty MELISA positive patients suffered from serious health problems (various allergies, autoimmune diseases, Parkinson's syndrome etc.). Nickel and inorganic mercury were the most common sensitizers in vitro. The cytokine assay revealed that mercury chloride activated predominantly TH2 lymphocytes, while nickel chloride activated mainly TH1 lymphocytes. CONCLUSIONS: Metallic pigmentations in the oral cavity demonstrate a corrosion process and may pose a risk in immunologically susceptible patients.
Neuro Endocrinol Lett. 2007 Oct;28(5):iii PubMed
The mechanism of gingiva metallic pigmentations formation
