We report here a case of congenital syphilis in a newborn after clindamycin treatment in pregnancy. Using PCR detection of tmpC (TP0319) and DNA sequencing of the genes TP0136 and TP0548, DNA sequences identical to Treponema pallidum subsp. pallidum strain SS14 were detected in the infant's skin lesions, serum, and cerebrospinal fluid.

Department of Medical Microbiology Faculty of Medicine Masaryk University Pekarska 53 656 91 Brno Czech Republic

Zobrazit více v PubMed

Atkins, D., K. A. Workowski, et al. 2006. Sexually transmitted diseases treatment guidelines, 2006. Morb. Mortal. Wkly. Rep. 55:1-94.

Brause, B. D., J. S. Borges, and R. B. Roberts. 1976. Relative efficacy of clindamycin, erythromycin, and penicillin in treatment of Treponema pallidum in skin syphilomas of rabbits. J. Infect. Dis. 134:93-96. PubMed

Flasarova, M., D. Smajs, P. Matejkova, V. Woznicova, M. Heroldova-Dvorakova, and M. Votava. 2006. Molecular detection and subtyping of Treponema pallidum subsp. pallidum in clinical specimens. Epidemiol. Mikrobiol. Immunol. 55:105-111. PubMed

Grimprel, E., P. J. Sanchez, G. D. Wendel, J. M. Burstain, G. H. McCracken, J. D. Radolf, and M. V. Norgard. 1991. Use of polymerase chain reaction and rabbit infectivity testing to detect Treponema pallidum in amniotic fluid, fetal and neonatal sera, and cerebrospinal fluid. J. Clin. Microbiol. 29:1711-1718. PubMed PMC

Koh, M. T., and C. T. Lim. 1991. Early congenital syphilis: experience with 13 consecutive cases seen at the University Hospital, Kuala Lumpur. Singapore Med. J. 32:230-232. PubMed

Liu, C. C., W. C. So, C. H. Lin, and T. F. Yeh. 1993. Congenital syphilis: clinical manifestations in premature infants. Scand. J. Infect. Dis. 25:741-745. PubMed

Michelow, I. C., G. D. Wendel, M. V. Norgard, F. Zeray, N. K. Leos, R. Alsaadi, and P. J. Sanchez. 2002. Central nervous system infection in congenital syphilis. N. Engl. J. Med. 346:1792-1798. PubMed

Meljanac, N., E. Dippel, and C. C. Zouboulis. 1999. Superimposed primary chancre in a patient with Adamantiades-Behcet's disease. Sex. Transm. Infect. 75:124-125. PubMed PMC

Sanchez, P. J., G. D. Wendel, Jr., E. Grimprel, M. Goldberg, M. Hall, O. Arencibia-Mireles, J. D. Radolf, and M. V. Norgard. 1993. Evaluation of molecular methodologies and rabbit infectivity testing for the diagnosis of congenital syphilis and neonatal central nervous system invasion by Treponema pallidum. J. Infect. Dis. 167:148-157. PubMed

Wenhai, L., Z. Jianzhong, and Y. Cao. 2004. Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate. Dermatology 208:94-97. PubMed

Wu, C. C., C. N. Tsai, W. R. Wong, H. S. Hong, and Y. H. Chuang. 2006. Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction. J. Am. Acad. Dermatol. 55:S11-15. PubMed

A new typing scheme demonstrates high discriminatory power for Treponema pallidum subspecies

Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Treponema paraluisleporidarum Ecovar Cuniculus) in the Focus of Infection

Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes

Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme

Multi-locus sequence typing of Treponema pallidum subsp. pallidum present in clinical samples from France: Infecting treponemes are genetically diverse and belong to 18 allelic profiles

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively

Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide resistance

Comparison of CDC and sequence-based molecular typing of syphilis treponemes: tpr and arp loci are variable in multiple samples from the same patient

Structure of rrn operons in pathogenic non-cultivable treponemes: sequence but not genomic position of intergenic spacers correlates with classification of Treponema pallidum and Treponema paraluiscuniculi strains

Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws