The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18637714
DOI
10.33549/physiolres.931483
PII: 1483
Knihovny.cz E-resources
- MeSH
- Adiponectin blood MeSH
- Adrenalectomy * MeSH
- Biomarkers blood MeSH
- C-Reactive Protein metabolism MeSH
- Adult MeSH
- Down-Regulation MeSH
- Pheochromocytoma metabolism physiopathology surgery MeSH
- Weight Gain MeSH
- Blood Pressure MeSH
- Leptin blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Adrenal Gland Neoplasms metabolism physiopathology surgery MeSH
- Resistin blood MeSH
- Adipose Tissue metabolism MeSH
- Treatment Outcome MeSH
- Inflammation metabolism prevention & control MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adiponectin MeSH
- ADIPOQ protein, human MeSH Browser
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Leptin MeSH
- Resistin MeSH
- RETN protein, human MeSH Browser
The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study. Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels. Serum CRP levels were decreased by 50 % six months after surgical removal of pheochromocytoma (0.49+/-0.12 vs. 0.23+/-0.05 mg/l, p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery. We conclude that increased body weight in patients after surgical removal of pheochromocytoma is accompanied by an attenuation of subclinical inflammation probably due to catecholamine normalization. We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process.
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