Structural and chemical aspects of HPMA copolymers as drug carriers
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
19931329
DOI
10.1016/j.addr.2009.10.007
PII: S0169-409X(09)00380-9
Knihovny.cz E-resources
- MeSH
- Acrylamides administration & dosage chemistry MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Molecular Structure MeSH
- Drug Carriers administration & dosage chemistry MeSH
- Polymers administration & dosage chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Acrylamides MeSH
- N-(2-hydroxypropyl)methacrylamide MeSH Browser
- Drug Carriers MeSH
- Polymers MeSH
Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer conjugates with various drugs and other biologically active molecules are described and discussed in this chapter. The discussion is held from the viewpoint of design and structure of the polymer backbone and biodegradable spacer between a polymer and drug, structure and methods of attachment of the employed drugs to the carrier and structure and methods of conjugation with targeting moieties. Physicochemical properties of the water-soluble polymer-drug conjugates and polymer micelles including mechanisms of drug release are also discussed. Detailed description of biological behavior of the polymer-drug conjugates as well as application of the copolymers for surface modification and targeting of gene delivery vectors are not included, they are presented and discussed in separate chapters of this issue.
References provided by Crossref.org
HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3
