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PubMed

Záznam pochází z PubMed

Use of a novel transfer function to reduce repolarization interval hysteresis

Journal of interventional cardiac electrophysiology. 2010 Oct ; 29 (1) : 23-32. [epub] 20100713

J Interv Card Electrophysiol
ISSN 1572-8595 | 1383-875X
Zdroj

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid20625805

PubMed 20625805
DOI 10.1007/s10840-010-9500-x
Knihovny.cz E-zdroje

MeSH
dospělí MeSH
elektrokardiografie * MeSH
hodnocení rizik MeSH
hypertenze diagnóza patofyziologie MeSH
kardiostimulace umělá metody MeSH
kardiostimulátor * MeSH
kohortové studie MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
modely kardiovaskulární MeSH
následné studie MeSH
převodní systém srdeční patofyziologie MeSH
referenční hodnoty MeSH
senioři nad 80 let MeSH
senioři MeSH
srdeční frekvence fyziologie MeSH
syndrom dlouhého QT diagnóza terapie MeSH
výsledek terapie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH

BACKGROUND: Cardiac repolarization is assessed by the QT interval on the surface electrocardiogram and varies with the heart rate. Standard QT corrections (QTc) do not account for the lag in QT change following a change in heart rate (QT hysteresis). Our group has developed and tested a transfer function (TRF) model to assess the effectiveness of a dynamic model of QT/RR coupling in eliminating hysteresis. METHODS: We studied three groups: group I, healthy volunteers (n = 23, 41 ± 17 years); group II, hypertensive patients (n = 25, 45 ± 11 years); and group III, patients in a predominately paced rhythm (n = 5, 75 ± 6 years). To vary the heart rate, either exercise bicycling in the supine position (groups I and II) or manipulation of the pacemaker parameters (group III) was done. We then compared a dynamic TRF model with a model based on weighted averages of previous RR intervals. Two parameters were tested: root mean square (RMS) of the error signal between measured and computed QT and the elimination of hysteretic loops. RESULTS: TRF-based measurements eliminated hysteresis in 22/23 (95%) group I patients, 21/25 (84%) group II patients, and 4/5 (80%) group III patients. When hysteresis elimination was not complete, the QT drift that followed RR intervals was different before and after bicycling (100 ms). In these patients, the corresponding QT interval did not significantly change during this period. The TRF model was found superior to the other tested models with respect to both analyzed parameters (RMS and hysteresis elimination). CONCLUSION: The TRF model limited QT hysteresis in healthy, hypertensive, and pacemaker-dependent patients. In addition, an important finding of QT drift in patients with hypertension was identified. With further study in these and other diseased states, the TRF model may improve our ability to measure accurately cardiac repolarization and to determine arrhythmia risk.

Institute of Scientific Instruments Brno Czech

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