The association of taxane resistance genes with the clinical course of ovarian carcinoma
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23542236
DOI
10.1016/j.ygeno.2013.03.005
PII: S0888-7543(13)00058-X
Knihovny.cz E-resources
- Keywords
- Clinical course, Cytokinesis, Gene expression, Ovarian carcinoma, Resistance, Taxane,
- MeSH
- ATP-Binding Cassette Transporters genetics MeSH
- Adenocarcinoma diagnosis drug therapy genetics MeSH
- Antineoplastic Agents therapeutic use MeSH
- Drug Resistance, Neoplasm genetics MeSH
- Genetic Association Studies MeSH
- Intracellular Signaling Peptides and Proteins genetics MeSH
- Caspases genetics MeSH
- Kinesins genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Ovarian Neoplasms diagnosis drug therapy genetics MeSH
- Oncogene Proteins genetics MeSH
- Ovary metabolism MeSH
- Peritoneum metabolism MeSH
- Bridged-Ring Compounds therapeutic use MeSH
- Disease Progression MeSH
- Protein Serine-Threonine Kinases genetics MeSH
- Cell Cycle Proteins genetics MeSH
- Taxoids therapeutic use MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- Antineoplastic Agents MeSH
- citron-kinase MeSH Browser
- Intracellular Signaling Peptides and Proteins MeSH
- Caspases MeSH
- KIF14 protein, human MeSH Browser
- Kinesins MeSH
- Oncogene Proteins MeSH
- PRC1 protein, human MeSH Browser
- Bridged-Ring Compounds MeSH
- Protein Serine-Threonine Kinases MeSH
- Cell Cycle Proteins MeSH
- taxane MeSH Browser
- Taxoids MeSH
Taxane and platinum-based chemotherapy regimens are standard treatment for advanced ovarian carcinoma. Expression levels of putative markers of taxane resistance in carcinoma tissues and paired peritoneal samples (n=55) and in 16 samples of ovaries without signs of carcinoma were compared with clinical data and the patients' time to progression. KIF14, PRC1, CIT and ABCC1 genes were significantly overexpressed in carcinomas when compared with normal ovarian tissues, while ABCB1 and CASP9 expression was decreased. Associations of protein expression of the proliferation marker Ki-67 with KIF14, PRC1, ABCB1 and CASP2 were found. Lastly, it was discovered that ABCB1 and CASP2 levels associated with FIGO stage and that the CIT level associated with the time to progression of ovarian carcinoma patients (P<0.0001). In conclusion, ABCB1, CASP2, KIF14, PRC1 and CIT genes seem to associate with surrogate markers of ovarian carcinoma progression and CIT gene associates with therapy outcome.
References provided by Crossref.org
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