Comparative analysis of IL-8 and CXCL-1 production by normal and cancer stromal fibroblasts
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
23890481
PII: file/5691/FB2013A0018.pdf
Knihovny.cz E-resources
- MeSH
- Stromal Cells metabolism MeSH
- Chemokine CXCL1 metabolism MeSH
- Fibroblasts metabolism MeSH
- Wound Healing physiology MeSH
- Interleukin-8 metabolism MeSH
- Keratinocytes physiology MeSH
- Coculture Techniques MeSH
- Culture Media, Conditioned MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Neoplasm Proteins metabolism MeSH
- Hypopharyngeal Neoplasms metabolism pathology MeSH
- Skin Neoplasms metabolism pathology MeSH
- Secretory Rate MeSH
- Dermis cytology MeSH
- Carcinoma, Squamous Cell metabolism pathology MeSH
- Up-Regulation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Chemokine CXCL1 MeSH
- CXCL1 protein, human MeSH Browser
- Interleukin-8 MeSH
- Culture Media, Conditioned MeSH
- Neoplasm Proteins MeSH
It has been shown that fibroblasts within the stroma of malignant tumours can affect the tumour's biological character, influencing such properties as local aggressiveness and metastasis potential. This influence is asserted via paracrine secretion of multiple cell factors, including chemokines. This study demonstrates that both normal keratinocytes and cancer cells can stimulate the secretion of chemokines IL-8 and CXCL-1 from normal dermal fibroblasts and stromal fibroblasts from squamous cell carcinoma. The effect of epithelia on normal fibroblasts leads to a transient secretory change, in contrast to stromal fibroblasts which generate a more prolonged one. This observation demonstrates that stimulated expression of both IL-8 and CXCL-1 is not specific to cancer, supporting the hypothesis that similar mechanisms exist between wound healing and oncogenesis. It also shows that stromal fibroblasts isolated from a tumour have significantly different features from normal fibroblasts.
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