The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats
Language English Country Czech Republic Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24020816
DOI
10.33549/physiolres.932637
PII: 932637
Knihovny.cz E-resources
- MeSH
- Anesthetics pharmacology MeSH
- Chloralose pharmacology MeSH
- Urethane pharmacology MeSH
- Ganglionic Blockers pharmacology MeSH
- Hypertension metabolism physiopathology MeSH
- Angiotensin-Converting Enzyme Inhibitors pharmacology MeSH
- Enzyme Inhibitors pharmacology MeSH
- Isoflurane pharmacology MeSH
- Ketamine pharmacology MeSH
- Anesthetics, Combined pharmacology MeSH
- Blood Pressure drug effects MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Nitric Oxide pharmacology MeSH
- Pentobarbital pharmacology MeSH
- Rats, Inbred SHR MeSH
- Rats, Wistar MeSH
- Renin-Angiotensin System drug effects MeSH
- Sympathetic Nervous System drug effects physiopathology MeSH
- Nitric Oxide Synthase antagonists & inhibitors metabolism MeSH
- Xylazine pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Anesthetics MeSH
- Chloralose MeSH
- Urethane MeSH
- Ganglionic Blockers MeSH
- Angiotensin-Converting Enzyme Inhibitors MeSH
- Enzyme Inhibitors MeSH
- Isoflurane MeSH
- Ketamine MeSH
- Anesthetics, Combined MeSH
- Nitric Oxide MeSH
- Pentobarbital MeSH
- Nitric Oxide Synthase MeSH
- Xylazine MeSH
Most anesthetics induce characteristic hemodynamic changes leading to blood pressure (BP) reduction but the role of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and nitric oxide (NO) synthesis in this BP reduction is unknown. We therefore studied the influence of four widely used anesthetics - pentobarbital (P), isoflurane (ISO), ketamine-xylazine (KX) and chloralose-urethane (CU) - on the participation of these vasoactive systems in BP maintenance. BP effects elicited by the acute sequential blockade of RAS (captopril), SNS (pentolinium) and NO synthase (L-NAME) were compared in conscious and anesthetized Wistar or spontaneously hypertensive rats (SHR). Except for pentobarbital all studied anesthetics evidenced by diminished BP responses to pentolinium. The absolute pentolinium-induced BP changes were always greater in SHR than Wistar rats. KX anesthesia eliminated BP response to pentolinium and considerably enhanced BP response to NO synthase inhibition in SHR. In both rat strains the anesthesia with ISO or CU augmented BP response to captopril, decreased BP response to pentolinium and attenuated BP response to NO synthase inhibition. In conclusion, pentobarbital anesthesia had a modest influence on BP level and its maintenance by the above vasoactive systems. Isoflurane and chloralose-urethane anesthesia may be used in cardiovascular experiments if substantial BP decrease due to altered contribution of RAS, SNS and NO to BP regulation does not interfere with the respective research aim. Major BP reduction (namely in SHR) due to a complete SNS absence is a major drawback of ketamine-xylazine anesthesia.
References provided by Crossref.org
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
Purinoceptors, renal microvascular function and hypertension
