Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24211256
DOI
10.1016/j.nlm.2013.10.015
PII: S1074-7427(13)00210-4
Knihovny.cz E-resources
- Keywords
- Cognitive coordination, Nogo-A, Spatial mazes, Spatial navigation, Transgenic rat model,
- MeSH
- Maze Learning physiology MeSH
- Down-Regulation * MeSH
- Gene Knockdown Techniques MeSH
- Rats MeSH
- Myelin Proteins genetics metabolism MeSH
- Nogo Proteins MeSH
- Rats, Sprague-Dawley MeSH
- Rats, Transgenic MeSH
- Spatial Behavior physiology MeSH
- Avoidance Learning physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Myelin Proteins MeSH
- Nogo Proteins MeSH
- Rtn4 protein, rat MeSH Browser
Nogo-A protein is an important inhibitor of axonal growth, which also regulates neuronal plasticity in the CNS. Mutations in the gene encoding Nogo-A or abnormalities in Nogo-A expression are linked to neuropsychiatric disorders such as schizophrenia. The present study assesses the impact of constitutively reduced expression of Nogo-A on place navigation in a novel transgenic rat model. Two spatial paradigms were used: (1) A battery of tests in the Carousel maze requiring continuous processing of spatial information with increasing demands for the segregation of reference frames and behavioral flexibility and (2) a delayed-matching-to-place version of the Morris water maze (MWM), which requires place navigation and is sensitive to deficits in one-trial-encoded place representation. The Carousel maze testing revealed a subtle but significant impairment in management of reference frames. Matching-to-place learning in the Morris water maze was unaffected, suggesting an intact representation of an unmarked goal. Our results show that Nogo-A deficiency leads to cognitive deficit in processing of the reference frames. Such a deficit may be the result of neuro-developmental alterations resulting from Nogo-A deficiency.
References provided by Crossref.org
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