The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24315797
DOI
10.1016/j.jcv.2013.11.004
PII: S1386-6532(13)00482-4
Knihovny.cz E-resources
- Keywords
- AIN, AIS, ASC-H, Anal cancer, Anal infection, CIN, CIN 2+, COC, Cervical infection, DNA, HIV, HPV, HR, HRT, HSIL, IUD, LR, OR, PCR, adenocarcinoma in situ, anal intraepithelial neoplasia, atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, cervical intraepithelial neoplasia, combined oral contraception, deoxyribonucleic acid, high-grade squamous intraepithelial lesion, high-gradeCIN or microinvasive cervical cancer, high-risk, hormone replacement therapy, human immunodeficiency virus, human papillomavirus, intrauterine device, low-risk, odd ratio, polymerase chain reaction,
- MeSH
- Anal Canal virology MeSH
- Cervix Uteri virology MeSH
- Adult MeSH
- Uterine Cervical Dysplasia virology MeSH
- Genotype MeSH
- Papillomavirus Infections complications epidemiology transmission virology MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Molecular Epidemiology MeSH
- Papillomaviridae classification genetics isolation & purification MeSH
- Surveys and Questionnaires MeSH
- Sexual Behavior MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: More than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor. OBJECTIVES: To demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer. STUDY DESIGN: A total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test. RESULTS: Cervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection. CONCLUSIONS: Concurrent anal and cervical HR HPV infection was found in nearly half of women with CIN 2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection.
References provided by Crossref.org
The association among cervical, anal, and oral HPV infections in high-risk and low-risk women
