Outbreak of fungal endophthalmitis due to Fusarium oxysporum following cataract surgery
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antifungal Agents therapeutic use MeSH
- Endophthalmitis drug therapy epidemiology microbiology MeSH
- Disease Outbreaks MeSH
- Cataract Extraction adverse effects MeSH
- Fusariosis drug therapy epidemiology microbiology MeSH
- Fusarium pathogenicity MeSH
- Middle Aged MeSH
- Humans MeSH
- Eye Infections, Fungal drug therapy MeSH
- Postoperative Complications microbiology MeSH
- Pyrimidines therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Triazoles therapeutic use MeSH
- Vitrectomy MeSH
- Voriconazole MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Pyrimidines MeSH
- Triazoles MeSH
- Voriconazole MeSH
Outbreak of exogenous Fusarium endophthalmitis after cataract surgery was evaluated. Twenty patients developed postoperative endophthalmitis. In 19 eyes, pars plana vitrectomy (PPV) was performed, in 14 cases (74 %) with primary intraocular lens explantation. In one case, the PPV was not performed because of poor general condition of the patient. Symptoms of endophthalmitis (damaged vision, iritis, tyndallization in anterior chamber, hypopyon) occurred at intervals of 16-79 days (mean 31.3 days). Fungal etiology was documented in 12 eyes (60 %). Fusarium oxysporum was evidenced by culture and/or microscopy and confirmed by PCR and sequencing analysis. Eighteen (90 %) patients were treated with oral voriconazole (400 mg/day) for a period of 4-6 weeks. The final visual acuity was 6/15 in 1 case (5 %), 6/60 and worse in 17 eyes (85 %), and in 2 cases (10 %), enucleation had to be performed. Viscoelastic filling material was suggested the most likely source of infection. Endophthalmitis caused by Fusarium spp. are a potentially big threat for patients with serious impact on vision. Successful management of the infection is highly dependent on early diagnosis including species identification and antifungal susceptibility testing, and on aggressive and long-term treatment.
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Mycopathologia. 2006 Jan;161(1):43-52 PubMed
Ophthalmology. 1998 Mar;105(3):522-6 PubMed
J Antimicrob Chemother. 2008 Mar;61(3):616-20 PubMed
Ophthalmology. 2008 Sep;115(9):1501-7, 1507.e1-2 PubMed
Clin Microbiol Infect. 2009 Jul;15(7):634-42 PubMed
J Clin Microbiol. 2009 May;47(5):1463-8 PubMed
Arch Ophthalmol. 1980 Jun;98(6):1025-39 PubMed
Br J Ophthalmol. 2008 Jul;92(7):871-8 PubMed
Mycopathologia. 2006 Sep;162(3):245-53 PubMed
Am J Ophthalmol. 2004 May;137(5):820-5 PubMed
Pharmacogenomics. 2011 Jun;12(6):861-72 PubMed
Am J Ophthalmol. 2005 Sep;140(3):552-4 PubMed
Eur J Clin Microbiol Infect Dis. 2009 Jun;28(6):613-22 PubMed
Mycopathologia. 2012 Sep;174(3):233-7 PubMed
Clin Microbiol Rev. 2000 Oct;13(4):662-85 PubMed
Eye (Lond). 2008 Jan;22(1):13-7 PubMed
Cornea. 2003 May;22(4):300-3 PubMed
Antimicrob Agents Chemother. 2011 Nov;55(11):5150-4 PubMed
Infection. 2013 Feb;41(1):15-20 PubMed
Clin Microbiol Rev. 2003 Oct;16(4):730-97 PubMed
Mycopathologia. 2011 Jun;171(6):431-4 PubMed
Invest Ophthalmol Vis Sci. 2009 May;50(5):2230-6 PubMed
Cesk Oftalmol. 1988 Sep;44(5):362-8 PubMed
J Antimicrob Chemother. 2009 Oct;64(4):877-8 PubMed
Southeast Asian J Trop Med Public Health. 2012 Nov;43(6):1484-8 PubMed
Am J Ophthalmol. 2007 Feb;143(2):222-227 PubMed
Mycopathologia. 2010 Nov;170(5):291-313 PubMed
Clin Ophthalmol. 2010 Mar 24;4:121-35 PubMed
Clin Microbiol Rev. 2007 Oct;20(4):695-704 PubMed
Ocul Immunol Inflamm. 2000 Sep;8(3):189-200 PubMed
Curr Opin Ophthalmol. 2008 Jul;19(4):302-6 PubMed
J Hosp Infect. 1997 Jul;36(3):223-8 PubMed
Curr Eye Res. 2009 Nov;34(11):988-95 PubMed
Eye Contact Lens. 2012 Sep;38(5):331-5 PubMed
Am J Ophthalmol. 2001 Nov;132(5):609-17 PubMed
Cornea. 2013 May;32(5):667-73 PubMed
Diagn Microbiol Infect Dis. 2008 Nov;62(3):348-50 PubMed
J Ocul Pharmacol Ther. 2006 Dec;22(6):437-9 PubMed
Br J Ophthalmol. 2002 Jul;86(7):829-30 PubMed
Mycoses. 2011 Nov;54(6):e767-74 PubMed
Arch Ophthalmol. 2007 Jun;125(6):789-93 PubMed
J Clin Microbiol. 2005 Oct;43(10):5372-5 PubMed
