Psilocybin--summary of knowledge and new perspectives
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24444771
DOI
10.1016/j.euroneuro.2013.12.006
PII: S0924-977X(13)00351-9
Knihovny.cz E-resources
- Keywords
- 5-HT1 receptors, 5-HT2 receptors, Behavioral studies, Brain imaging, Hallucinogenic mushrooms, Hallucinogens, Neurobiology, Pharmacology, Psilocybin, Psychedelics, Psychological measures, Serotonin,
- MeSH
- Behavior, Animal drug effects MeSH
- Hallucinogens adverse effects pharmacokinetics pharmacology therapeutic use MeSH
- Humans MeSH
- Brain drug effects MeSH
- Substance-Related Disorders MeSH
- Psilocybin adverse effects pharmacokinetics pharmacology therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Hallucinogens MeSH
- Psilocybin MeSH
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential.
References provided by Crossref.org
Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids
Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms
The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action
Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting
The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat