Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential.

Prague Psychiatric Center Prague Czech Republic; 3rd Faculty of Medicine Charles University Prague Czech Republic

References provided by Crossref.org

Exploring Psilocybe cubensis Strains: Cultivation Techniques, Psychoactive Compounds, Genetics and Research Gaps

Back from the rabbit hole. Theoretical considerations and practical guidelines on psychedelic integration for mental health specialists

Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats

Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids

Psilocybin-Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience

Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms

The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action

Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting

Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing-study on P300 and mismatch negativity in healthy volunteers

The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat