Spatial navigation: implications for animal models, drug development and human studies
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24564663
DOI
10.33549/physiolres.932660
PII: 932660
Knihovny.cz E-resources
- MeSH
- Maze Learning drug effects physiology MeSH
- Central Nervous System Agents pharmacology MeSH
- Humans MeSH
- Brain drug effects physiology MeSH
- Memory drug effects physiology MeSH
- Spatial Behavior drug effects physiology MeSH
- Drug Design * MeSH
- Space Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Central Nervous System Agents MeSH
Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior.
References provided by Crossref.org
Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation
