Investigation of drug-polymer interaction in solid dispersions by vapour sorption methods
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24751346
DOI
10.1016/j.ijpharm.2014.04.048
PII: S0378-5173(14)00284-1
Knihovny.cz E-resources
- Keywords
- Dissolution rate, Drug–polymer interaction, Hydrogen bond, Solid dispersion, Spray drying, Water sorption,
- MeSH
- Adsorption MeSH
- Models, Chemical MeSH
- Technology, Pharmaceutical methods MeSH
- Kinetics MeSH
- Crystallography, X-Ray MeSH
- Polymethacrylic Acids chemistry MeSH
- Microscopy, Electron, Scanning MeSH
- Polyethylene Glycols chemistry MeSH
- Polymers chemistry MeSH
- Polyvinyls chemistry MeSH
- Povidone chemistry MeSH
- Solubility MeSH
- Tetrazoles chemistry MeSH
- Valine analogs & derivatives chemistry MeSH
- Valsartan MeSH
- Water chemistry MeSH
- Hydrogen Bonding MeSH
- Volatilization MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Eudragit E PO MeSH Browser
- Polymethacrylic Acids MeSH
- Polyethylene Glycols MeSH
- Polymers MeSH
- polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer MeSH Browser
- Polyvinyls MeSH
- Povidone MeSH
- Tetrazoles MeSH
- Valine MeSH
- Valsartan MeSH
- Water MeSH
The objective of this study was to investigate the effect of different polymeric carriers in solid dispersions with an active pharmaceutical ingredient (API) on their water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, scanning electron microscopy (SEM), moisture sorption analysis, infrared (IR) spectroscopy and dissolution tests were performed on various API-polymer systems (Valsartan as API with Soluplus, PVP and Eudragit polymers) after production of amorphous solid dispersions by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherms were lower in comparison with the isotherms of physical mixtures in all combinations with Soluplus and PVP. In contrast, the moisture sorption isotherms of solid dispersions containing Eudragit were significantly higher than the corresponding physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. A correlation between the dissolution rate and the water sorption properties of the API-polymer systems has been established.
References provided by Crossref.org
The Combined Use of Imaging Approaches to Assess Drug Release from Multicomponent Solid Dispersions
