Investigation of drug-polymer interaction in solid dispersions by vapour sorption methods
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
24751346
DOI
10.1016/j.ijpharm.2014.04.048
PII: S0378-5173(14)00284-1
Knihovny.cz E-zdroje
- Klíčová slova
- Dissolution rate, Drug–polymer interaction, Hydrogen bond, Solid dispersion, Spray drying, Water sorption,
- MeSH
- adsorpce MeSH
- chemické modely MeSH
- farmaceutická technologie metody MeSH
- kinetika MeSH
- krystalografie rentgenová MeSH
- kyseliny polymethakrylové chemie MeSH
- mikroskopie elektronová rastrovací MeSH
- polyethylenglykoly chemie MeSH
- polymery chemie MeSH
- polyvinyly chemie MeSH
- povidon chemie MeSH
- rozpustnost MeSH
- tetrazoly chemie MeSH
- valin analogy a deriváty chemie MeSH
- valsartan MeSH
- voda chemie MeSH
- vodíková vazba MeSH
- volatilizace MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- Eudragit E PO MeSH Prohlížeč
- kyseliny polymethakrylové MeSH
- polyethylenglykoly MeSH
- polymery MeSH
- polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer MeSH Prohlížeč
- polyvinyly MeSH
- povidon MeSH
- tetrazoly MeSH
- valin MeSH
- valsartan MeSH
- voda MeSH
The objective of this study was to investigate the effect of different polymeric carriers in solid dispersions with an active pharmaceutical ingredient (API) on their water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, scanning electron microscopy (SEM), moisture sorption analysis, infrared (IR) spectroscopy and dissolution tests were performed on various API-polymer systems (Valsartan as API with Soluplus, PVP and Eudragit polymers) after production of amorphous solid dispersions by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherms were lower in comparison with the isotherms of physical mixtures in all combinations with Soluplus and PVP. In contrast, the moisture sorption isotherms of solid dispersions containing Eudragit were significantly higher than the corresponding physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. A correlation between the dissolution rate and the water sorption properties of the API-polymer systems has been established.
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