Coordination of cell division and pattern formation is central to tissue and organ development, particularly in plants where walls prevent cell migration. Auxin and cytokinin are both critical for division and patterning, but it is unknown how these hormones converge upon tissue development. We identify a genetic network that reinforces an early embryonic bias in auxin distribution to create a local, nonresponding cytokinin source within the root vascular tissue. Experimental and theoretical evidence shows that these cells act as a tissue organizer by positioning the domain of oriented cell divisions. We further demonstrate that the auxin-cytokinin interaction acts as a spatial incoherent feed-forward loop, which is essential to generate distinct hormonal response zones, thus establishing a stable pattern within a growing vascular tissue.

Department of Biology University of Pennsylvania Philadelphia PA 190104 6084 USA

Department of Plant Systems Biology VIB Technologiepark 927 9052 Gent Belgium Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 9052 Gent Belgium

Division of Human Nutrition Wageningen University Dreijenlaan 2 6703HA Wageningen the Netherlands

Division of Human Nutrition Wageningen University Dreijenlaan 2 6703HA Wageningen the Netherlands TI Food and Nutrition 6703HA Wageningen the Netherlands

Laboratory of Biochemistry Wageningen University Dreijenlaan 3 6703HA Wageningen the Netherlands

Laboratory of Systems and Synthetic Biology Wageningen University Dreijenlaan 3 6703HA Wageningen the Netherlands

LifeGlimmer GmbH Markelstrasse 38 12163 Berlin Germany Albert Ludwigs University Freiburg Faculty of Biology Plant Biotechnology Schaenzlestrasse 1 D 79104 Freiburg Germany Laboratory of Systems and Synthetic Biology Wageningen University Dreijenlaan 3 6703HA Wageningen the Netherlands

Umeå Plant Science Centre Department of Forest Genetics and Plant Physiology SLU SE 901 83 Umeå Sweden

Umeå Plant Science Centre Department of Forest Genetics and Plant Physiology SLU SE 901 83 Umeå Sweden Laboratory of Growth Regulators Centre of the Region Haná for Biotechnological and Agricultural Research Palacký University and Institute of Experimental Botany AS CR Šlechtitelů 11 CZ 78371 Olomouc Czech Republic

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Science. 2014 Aug 8;345(6197):622-3. doi: 10.1126/science.1257843. PubMed

Citace poskytuje Crossref.org

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