Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25663641
DOI
10.1007/s00394-015-0856-7
PII: 10.1007/s00394-015-0856-7
Knihovny.cz E-zdroje
- Klíčová slova
- Catechins, Drug-metabolizing enzymes, Green tea extract, Metabolic syndrome, Obesity,
- MeSH
- antioxidancia farmakologie MeSH
- aromatické hydroxylasy genetika metabolismus MeSH
- čaj chemie MeSH
- cytochrom P-450 CYP2E1 genetika metabolismus MeSH
- cytochrom P-450 CYP3A genetika metabolismus MeSH
- ELISA MeSH
- glutamát sodný škodlivé účinky MeSH
- inzulin krev MeSH
- játra účinky léků metabolismus MeSH
- leptin krev MeSH
- messenger RNA genetika metabolismus MeSH
- modely nemocí na zvířatech MeSH
- myši obézní MeSH
- myši MeSH
- obezita chemicky indukované farmakoterapie MeSH
- potravní doplňky * MeSH
- rodina 2 cytochromů P450 MeSH
- rostlinné extrakty farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antioxidancia MeSH
- aromatické hydroxylasy MeSH
- čaj MeSH
- Cyp2a5 protein, mouse MeSH Prohlížeč
- cytochrom P-450 CYP2E1 MeSH
- cytochrom P-450 CYP3A MeSH
- cytochrome P450 3A4, mouse MeSH Prohlížeč
- glutamát sodný MeSH
- inzulin MeSH
- leptin MeSH
- messenger RNA MeSH
- rodina 2 cytochromů P450 MeSH
- rostlinné extrakty MeSH
PURPOSE: Consumption of dietary supplements with green tea extract (GTE) is popular for weight management, but it may be accompanied by various side effects, including interactions with drugs. The aim of the present in vivo study was to evaluate the effect of defined GTE (Polyphenon 60) in three dosage schemes on insulin, leptin and drug-metabolizing enzymes in obese mice. METHODS: Experimental obesity was induced by repeated s.c. application of monosodium glutamate to newborn mice. Green tea extract was administered in three dosage schemes in chow diet. The plasmatic levels of insulin and leptin were assayed using enzyme-linked immunosorbent assay. Enzyme activities and mRNA expressions of drug-metabolizing enzymes (totally 13) were analyzed in liver and small intestine using spectrophotometric and HPLC assays and RT-PCR, respectively. RESULTS: GTE-treatment decreased insulin and leptin levels. Eleven enzymes were significantly affected by GTE-treatment. Long-term administration of 0.01% GTE caused increase in the activity and mRNA level of cytochrome P450 3A4 (CYP3A4) ortholog in the liver as well as in the small intestine. Interestingly, short-term overdose by GTE (0.1%) had more pronounced effects on enzyme activities and mRNA expressions than long-term overdose. CONCLUSIONS: GTE-mediated induction of CYP3A4 ortholog, the main drug-metabolizing enzyme, could result in decreased efficacy of simultaneously or subsequently administered drug in obese individuals.
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Science. 1969 May 9;164(3880):719-21 PubMed
Inflamm Bowel Dis. 2013 Aug;19(9):1904-12 PubMed
Methods Enzymol. 1981;77:218-31 PubMed
J Ethnopharmacol. 2007 Oct 8;114(1):66-71 PubMed
Curr Pharm Des. 2013;19(34):6141-7 PubMed
Arch Biochem Biophys. 2004 Mar 1;423(1):148-61 PubMed
Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):677-89 PubMed
PLoS One. 2014 Jan 17;9(1):e86033 PubMed
Toxicol Lett. 2012 Nov 15;214(3):328-38 PubMed
Eur J Pharmacol. 2011 Jul 15;662(1-3):1-8 PubMed
Arch Biochem Biophys. 1997 Oct 1;346(1):161-9 PubMed
Methods Mol Biol. 2006;320:73-83 PubMed
Biochemistry. 2001 Sep 11;40(36):10901-10 PubMed
Endocrinology. 2000 Mar;141(3):980-7 PubMed
Drug Metab Dispos. 2015 Feb;43(2):258-65 PubMed
Methods. 2001 Dec;25(4):402-8 PubMed
J Agric Food Chem. 2006 Mar 8;54(5):1599-603 PubMed
J Pharmacobiodyn. 1982 Oct;5(10):811-7 PubMed
Xenobiotica. 2012 Sep;42(9):872-9 PubMed
Physiol Res. 2008;57(5):727-34 PubMed
Evid Based Complement Alternat Med. 2012;2012:892697 PubMed
Dig Liver Dis. 2012 Sep;44(9):767-74 PubMed
Food Chem Toxicol. 2008 Apr;46(4):1271-8 PubMed
Anal Biochem. 1985 Oct;150(1):76-85 PubMed
Eur J Clin Nutr. 2001 Dec;55(12):1104-10 PubMed
Mol Immunol. 1989 Mar;26(3):221-30 PubMed
J Natl Cancer Inst. 1996 Mar 6;88(5):259-69 PubMed
Adv Nutr. 2012 Sep 01;3(5):734-5 PubMed
J Nat Prod. 2006 Mar;69(3):460-3 PubMed
J Pharmacol Exp Ther. 2002 Aug;302(2):490-6 PubMed
Cancer Res. 2003 Sep 1;63(17):5513-20 PubMed
PLoS One. 2012;7(1):e29837 PubMed
Life Sci. 2009 Sep 23;85(13-14):490-8 PubMed
Obesity (Silver Spring). 2007 Apr;15(4):798-808 PubMed
J Med Food. 2014 Mar;17(3):374-83 PubMed
Exp Anim. 2006 Apr;55(2):109-15 PubMed
Cochrane Database Syst Rev. 2012 Dec 12;12:CD008650 PubMed
Biochem Pharmacol. 2008 Sep 15;76(6):773-83 PubMed
Lancet. 2002 Oct 12;360(9340):1155-62 PubMed
Cell. 2009 Jan 23;136(2):215-33 PubMed
J Clin Invest. 2008 Sep;118(9):3160-9 PubMed
Indian J Pharmacol. 2013 Mar-Apr;45(2):136-40 PubMed
Int J Obes Relat Metab Disord. 1999 Jan;23(1):48-53 PubMed
Mol Nutr Food Res. 2013 May;57(5):833-9 PubMed
J Gastroenterol Hepatol. 2014 Sep;29(9):1736-43 PubMed
