Aberrant expression of the microRNA cluster in 14q32 is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25883014
DOI
10.1016/j.cancergen.2015.03.003
PII: S2210-7762(15)00034-4
Knihovny.cz E-resources
- Keywords
- 14q32, del(5q), lenalidomide, miRNA, myelodysplastic syndrome,
- MeSH
- Chromosome Deletion MeSH
- Immunologic Factors therapeutic use MeSH
- Angiogenesis Inhibitors therapeutic use MeSH
- Lenalidomide MeSH
- Humans MeSH
- Chromosomes, Human, Pair 14 genetics MeSH
- Chromosomes, Human, Pair 5 genetics MeSH
- MicroRNAs genetics MeSH
- Myelodysplastic Syndromes drug therapy genetics MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Oligonucleotide Array Sequence Analysis MeSH
- Sequence Deletion MeSH
- Gene Expression Profiling MeSH
- Case-Control Studies MeSH
- Thalidomide analogs & derivatives therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunologic Factors MeSH
- Angiogenesis Inhibitors MeSH
- Lenalidomide MeSH
- MicroRNAs MeSH
- Thalidomide MeSH
Lenalidomide is a novel thalidomide analogue with immunomodulatory and antiangiogenic effects that has been successfully used for the treatment of low and intermediate-1 risk myelodysplastic syndromes (MDSs) with a del(5q) aberration. Because information about the influence of lenalidomide on the microRNA (miRNA) transcriptome is limited, we performed miRNA expression profiling of bone marrow CD34+ cells obtained from MDS patients with the del(5q) abnormality who had been subjected to lenalidomide treatment. To define differences in miRNA expression, we performed paired data analysis to compare the miRNA profiles of patients before and during lenalidomide treatment and those of healthy donors. The analysis showed that miRNAs clustering to the 14q32 region had a higher expression level in patient samples before treatment than in the healthy control samples, and this elevated expression was diminished following lenalidomide administration. Because some of the 14q32 miRNAs play important roles in hematopoiesis, stem cell differentiation, and apoptosis induction, the expression of this cluster may be associated with the pathophysiology of the disease.
1st Department of Medicine General University Hospital Prague Czech Republic
Institute of Hematology and Blood Transfusion Prague Czech Republic
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