Translation in the mammalian oocyte in space and time
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26340983
DOI
10.1007/s00441-015-2269-6
PII: 10.1007/s00441-015-2269-6
Knihovny.cz E-zdroje
- Klíčová slova
- Meiosis, Oocyte, RNA, RNP, Translation,
- MeSH
- lidé MeSH
- meióza MeSH
- oocyty cytologie metabolismus MeSH
- oogeneze MeSH
- proteosyntéza * MeSH
- RNA analýza genetika MeSH
- transkriptom MeSH
- vývojová regulace genové exprese MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- RNA MeSH
A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Post-transcriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
CEITEC Veterinary Research Institute Hudcova 296 70 621 00 Brno Czech Republic
Institute of Animal Physiology and Genetics ASCR Rumburska 89 277 21 Libechov Czech Republic
Citace poskytuje Crossref.org
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