"Non-Taxifolin" Derived Flavonolignans: Phytochemistry and Biology
Jazyk angličtina Země Spojené arabské emiráty Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26429716
DOI
10.2174/1381612821666151002112720
PII: CPD-EPUB-70836
Knihovny.cz E-zdroje
- MeSH
- antiflogistika chemie izolace a purifikace farmakologie MeSH
- antioxidancia chemie izolace a purifikace farmakologie MeSH
- flavonolignany chemie izolace a purifikace farmakologie MeSH
- fytonutrienty chemie izolace a purifikace farmakologie MeSH
- lidé MeSH
- ostropestřec mariánský MeSH
- protinádorové látky chemie izolace a purifikace farmakologie MeSH
- quercetin analogy a deriváty chemie izolace a purifikace farmakologie MeSH
- rostlinné extrakty chemie izolace a purifikace farmakologie MeSH
- Staphylococcus aureus účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antiflogistika MeSH
- antioxidancia MeSH
- flavonolignany MeSH
- fytonutrienty MeSH
- protinádorové látky MeSH
- quercetin MeSH
- rostlinné extrakty MeSH
- taxifolin MeSH Prohlížeč
Flavonolignans are plant natural products, composed of a flavonoid moiety and a lignan (phenylpropanoid) part. Current literature focuses on flavonolignans formed from taxifolin and coniferyl alcohol as e.g. silybin and its congeners from fruit extract from the purple variety of the milk thistle (Silybum marianum) denoted as "silymarin". This review describes chemistry and biological activity of so far neglected "non-taxifolin" based flavonolignans, derived from apigenin, luteolin, tricin, chrysoeriol, naringenin and eriodictyol, as the flavonoid part. Up-to-date knowledge on hydnocarpin, hydnocarpin-D, pseudotsuganol, hydnowightin, neohydnocarpin, palstatin, salcolins A and B, anastatins A and B, sinaiticin, silyamandin and silandrin is summarized in the present paper. Most of non-taxifolin derived flavonolignans have been shown to exhibit in vitro and/or in vivo anti-hepatotoxic, anti-oxidant, free radical scavenging, anti-inflammatory, anti-proliferative, anti-cancer, chemotherapy potentiating, anti-melanogenic, anti-bacterial, vasorelaxing, anti-platelet aggregation and/or hypotriglyceridemic activity, often stronger than silybin. Many of these compounds inhibited Staphylococcus aureus multidrug resistance pump NorA and sensitized multidrug resistant cancer cell lines showing a potential as adjuvants. Non-taxifolin derived flavonolignans are a relatively unexplored group of compounds with interesting biological activity and great application potential. Their detailed study could provide a new insight into the biomimetic synthesis in order to obtain new compounds with greater activity and identify new lead structures for the biomedicinal research.
Citace poskytuje Crossref.org
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study
