"Non-Taxifolin" Derived Flavonolignans: Phytochemistry and Biology
Language English Country United Arab Emirates Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26429716
DOI
10.2174/1381612821666151002112720
PII: CPD-EPUB-70836
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents chemistry isolation & purification pharmacology MeSH
- Antioxidants chemistry isolation & purification pharmacology MeSH
- Flavonolignans chemistry isolation & purification pharmacology MeSH
- Phytochemicals chemistry isolation & purification pharmacology MeSH
- Humans MeSH
- Silybum marianum MeSH
- Antineoplastic Agents chemistry isolation & purification pharmacology MeSH
- Quercetin analogs & derivatives chemistry isolation & purification pharmacology MeSH
- Plant Extracts chemistry isolation & purification pharmacology MeSH
- Staphylococcus aureus drug effects MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Antioxidants MeSH
- Flavonolignans MeSH
- Phytochemicals MeSH
- Antineoplastic Agents MeSH
- Quercetin MeSH
- Plant Extracts MeSH
- taxifolin MeSH Browser
Flavonolignans are plant natural products, composed of a flavonoid moiety and a lignan (phenylpropanoid) part. Current literature focuses on flavonolignans formed from taxifolin and coniferyl alcohol as e.g. silybin and its congeners from fruit extract from the purple variety of the milk thistle (Silybum marianum) denoted as "silymarin". This review describes chemistry and biological activity of so far neglected "non-taxifolin" based flavonolignans, derived from apigenin, luteolin, tricin, chrysoeriol, naringenin and eriodictyol, as the flavonoid part. Up-to-date knowledge on hydnocarpin, hydnocarpin-D, pseudotsuganol, hydnowightin, neohydnocarpin, palstatin, salcolins A and B, anastatins A and B, sinaiticin, silyamandin and silandrin is summarized in the present paper. Most of non-taxifolin derived flavonolignans have been shown to exhibit in vitro and/or in vivo anti-hepatotoxic, anti-oxidant, free radical scavenging, anti-inflammatory, anti-proliferative, anti-cancer, chemotherapy potentiating, anti-melanogenic, anti-bacterial, vasorelaxing, anti-platelet aggregation and/or hypotriglyceridemic activity, often stronger than silybin. Many of these compounds inhibited Staphylococcus aureus multidrug resistance pump NorA and sensitized multidrug resistant cancer cell lines showing a potential as adjuvants. Non-taxifolin derived flavonolignans are a relatively unexplored group of compounds with interesting biological activity and great application potential. Their detailed study could provide a new insight into the biomimetic synthesis in order to obtain new compounds with greater activity and identify new lead structures for the biomedicinal research.
References provided by Crossref.org
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study
