Ceramides with ultralong chains (≥30 carbons), also known as acylceramides, play a critical role in the survival of mammals on dry land. An efficient and scalable synthesis of four major classes of ultralong human skin ceramides is reported. The key approach involves the use of a succinimidyl ester that acts as a protective group, helps overcome the extremely low solubility, and simultaneously activates the fatty acid for its clean and high-yielding attachment to a sphingoid base.

Faculty of Military Health Sciences University of Defense Hradec Králové 500 00 Czech Republic

Faculty of Pharmacy in Hradec Králové Charles University Prague Hradec Králové 500 05 Czech Republic

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