Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26498213
DOI
10.5507/bp.2015.048
Knihovny.cz E-zdroje
- Klíčová slova
- coeliac disease, inflammatory bowel diseases, psoriasis,
- MeSH
- C-reaktivní protein metabolismus MeSH
- časná diagnóza MeSH
- celiakie komplikace diagnóza epidemiologie MeSH
- chronická nemoc MeSH
- Crohnova nemoc komplikace diagnóza epidemiologie MeSH
- imunoglobulin A metabolismus MeSH
- kvalita života MeSH
- lidé MeSH
- počet leukocytů MeSH
- protilátky proti cytoplazmě neutrofilů metabolismus MeSH
- psoriáza komplikace epidemiologie MeSH
- studie případů a kontrol MeSH
- transglutaminasy metabolismus MeSH
- ulcerózní kolitida komplikace diagnóza epidemiologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- C-reaktivní protein MeSH
- imunoglobulin A MeSH
- protilátky proti cytoplazmě neutrofilů MeSH
- transglutaminasy MeSH
AIMS: The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. METHODS: This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases. RESULTS: There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis. CONCLUSION: Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.
Department of Dermatovenereology 2nd Faculty of Medicine Charles University Prague Czech Republic
Department of Epidemiology 2nd Faculty of Medicine Charles University Prague Czech Republic
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