Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- Keywords
- RNA, formamide, nucleobases, nucleotides, origin of life,
- MeSH
- Formamides chemistry MeSH
- Catalysis MeSH
- Oligonucleotides chemistry metabolism MeSH
- Origin of Life MeSH
- RNA chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Formamides MeSH
- Oligonucleotides MeSH
- RNA MeSH
50 years after the historical Miller-Urey experiment, the formamide-based scenario is perhaps the most powerful concurrent hypothesis for the origin of life on our planet besides the traditional HCN-based concept. The information accumulated during the last 15 years in this topic is astonishingly growing and nowadays the formamide-based model represents one of the most complete and coherent pathways leading from simple prebiotic precursors up to the first catalytically active RNA molecules. In this work, we overview the major events of this long pathway that have emerged from recent experimental and theoretical studies, mainly concentrating on the mechanistic, methodological, and structural aspects of this research.
References provided by Crossref.org
A Computational Quantum-Based Perspective on the Molecular Origins of Life's Building Blocks
RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview
Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context
Formation of nucleobases in a Miller-Urey reducing atmosphere
