Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27017494
DOI
10.1007/s12024-016-9764-2
PII: 10.1007/s12024-016-9764-2
Knihovny.cz E-zdroje
- Klíčová slova
- Catecholamines, Hypothermia, Metanephrines, Postmortem biochemistry, Vitreous humor,
- MeSH
- adrenalin metabolismus MeSH
- dopamin analogy a deriváty metabolismus MeSH
- dospělí MeSH
- hypotermie diagnóza metabolismus MeSH
- katecholaminy metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- metanefrin metabolismus MeSH
- mladý dospělý MeSH
- noradrenalin metabolismus MeSH
- normetanefrin metabolismus MeSH
- posmrtné změny MeSH
- senioři MeSH
- sklivec metabolismus MeSH
- soudní patologie MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 3-methoxytyramine MeSH Prohlížeč
- adrenalin MeSH
- dopamin MeSH
- katecholaminy MeSH
- metanefrin MeSH
- noradrenalin MeSH
- normetanefrin MeSH
PURPOSE: The aim of this study was to assess the diagnostic value of catecholamines and their O-methylated metabolites in vitreous humor samples in identifying antemortem cold exposure and fatal hypothermia in the forensic casework. METHODS: A total of 80 autopsy cases (40 hypothermia fatalities and 40 cases in which hypothermia as the main or contributory cause of death was excluded) were selected for this study. Catecholamines and their O-methylated metabolites were measured in urine and vitreous humor samples collected at autopsy. RESULTS: Urine catecholamine and their O-methylated metabolite concentrations were significantly higher in hypothermia-related deaths. On the other hand, measurements in vitreous humor samples did not reveal statistically significant differences between hypothermia-related deaths and controls. CONCLUSIONS: Globally considered, our findings seem to suggest that, contrary to urine catecholamines and their O-methylated metabolites, vitreous levels of these compounds appear to be of limited value in characterizing human antemortem stress reactions due to cold exposure and can hardly be used in the forensic setting to support the diagnosis of hypothermia.
Chair and Department of Forensic Medicine Medical University of Lublin Lublin Poland
Service de Biomédecine Lausanne University Hospital Lausanne Switzerland
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